ChemicalBook > CAS DataBase List > 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Structure
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE
  • CAS No.256414-75-2
  • Chemical Name:5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE
  • CBNumber:CB4131568
  • Molecular Formula:C20H10F6N2OS
  • Formula Weight:440.36
  • MOL File:256414-75-2.mol
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Property
  • Melting point 94.5-95.3 °C
  • Boiling point 490.3±55.0 °C(Predicted)
  • Density 1.415±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • solubility DMSO: 17 mg/mL
  • form solid
  • pka -3.48±0.43(Predicted)
  • color white
  • InChIKey OYMNPJXKQVTQTR-UHFFFAOYSA-N
  • UNSPSC Code 12352211
  • NACRES NA.77
Safety
  • Hazard Codes  :T
  • Risk Statements  :25
  • Safety Statements  :45
  • RIDADR  :UN 2811 6.1/PG 3
  • WGK Germany  :3
  • HS Code  :2934999090
  • NFPA 704:
    1
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300
  • Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: S3944
  • Product name : SEW2871
  • Purity: ≥98% (HPLC), solid
  • Packaging: 1MG
  • Price: ₹22505.18
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: S3944
  • Product name : SEW2871
  • Purity: ≥98% (HPLC), solid
  • Packaging: 5MG
  • Price: ₹101895.73
  • Updated: 2022/06/14
  • Buy: Buy

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Chemical Properties,Usage,Production

  • Description Sphingosine-1-phosphate receptor 1 (S1P1) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood. Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P3, the receptor responsible for regulation of heart rate. SEW2871 is a selective S1P1 receptor agonist in both human and mouse that is not active at the S1P2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.
  • Uses SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.
  • Uses 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE is used as medicament for treating and/or preventing cardiovascular conditions in patients with Fabry disease.
  • Definition ChEBI: 5-[4-phenyl-5-(trifluoromethyl)-2-thiophenyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole is an oxadiazole and a ring assembly.
  • Biological Activity Novel, potent and selective sphingosine-1-phosphate 1 (S1P 1 ) receptor agonist. Activates S1P 1 receptor with an EC 50 of 13 nM, but does not activate S1P 2 , S1P 3 , S1P 4 or S1P 5 receptors at concentrations up to 10 μ M. Cell-permeable and active in vivo .
  • Biochem/physiol Actions SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation. SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration. By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.
  • storage Store at RT
5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Spectrum
256414-75-2, 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLERelated Search:
  • Sulfur & Selenium Compounds
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Lysophospholipid receptor and related
  • 化学试剂
  • 抑制剂
  • 合成有机化合物配体
  • 抗体-二抗
  • 合成
  • C20H10F6N2OS
  • 化合物SEW2871,10 MM DMSO 溶液
  • SEW2871,S1P 1激动剂
  • 5-(4-苯基-5-(三氟甲基)噻吩-2-基)-3-(3-(三氟甲基)苯基)-1,2,4-恶二唑
  • 5-[4-苯基-5-(三氟甲基)-2-噻吩基]-3-[3-(三氟甲基)苯基]-1,2,4-噁二唑
  • 5-[4-苯基-5-(三氟甲基)-2-噻吩]-3-[3-(三氟甲基)苯基]-1,2,4-噁二唑
  • 5-[4-苯基-5-(三氟甲基)-2-噻吩基]-3-[3-(三氟甲基)苯基]-1,2,4-恶二唑
  • 256414-75-2
  • SEW2871, 10 mM in DMSO
  • SEW 2871, S1P1 agonist
  • 1,2,4-Oxadiazole, 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-
  • S1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem
  • S1P? Receptor Agonist, SEW2871
  • 5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole
  • SEW-2871, 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole
  • BUTTPARK 82\12-95
  • 5-[4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHEN-2-YL]-3-[3-(TRIFLUOROMETHYL)PHENYL]1,2,4-OXADIAZOLE
  • 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE
  • SW2871
  • SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONIST
  • SEW 2871

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