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verrucarin J

CAS No.4643-58-7
Chemical Name:verrucarin J
CBNumber:CB41313695
Molecular Formula:C27H32O8
Formula Weight:484.54
MOL File:4643-58-7.mol

verrucarin J Property

alpha D19 +54° (benzene); D22 +20 ± 2° (c = 1.011 in chloroform)
Boiling point 735.4±60.0 °C(Predicted)
Density 1.29±0.1 g/cm3(Predicted)
form powder
color White
FDA UNII 62UBU5Q68G

Safety

RIDADR :3172
HazardClass :6.1(a)
PackingGroup :I
HS Code :2941900000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H300+H310+H330
Precautionary statements P260-P262-P361+P364

verrucarin J Chemical Properties,Usage,Production

Uses Verrucarin J can be used in biological study of characteristics of toxigenic properties of Myrothecium cinctum and Myrothecium commune.
Definition ChEBI: Verrucarin j is a trichothecene.

in vivo

Verrucarin J (0.5?mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model^[2].
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis^[5].

Animal Model:	6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts^[2]
Dosage:	0.5?mg/kg body weight
Administration:	i.p. for 4 weeks
Result:	Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors.

Animal Model:	Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts^[5]
Dosage:	0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate)
Administration:	i.p. for three weeks after 10 days of injection of A2780 cells
Result:	Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg. Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg. Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg. In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments.