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Fludiazepam

Fludiazepam Structure
Fludiazepam
  • CAS No.3900-31-0
  • Chemical Name:Fludiazepam
  • CBNumber:CB4115212
  • Molecular Formula:C16H12ClFN2O
  • Formula Weight:302.73
  • MOL File:3900-31-0.mol
Fludiazepam Property
  • Melting point 88-92°; mp 69-72° (Sternbach)
  • Boiling point 498.1±45.0 °C(Predicted)
  • Density 1.3159 (estimate)
  • solubility DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 1 mg/ml
  • form A crystalline solid
  • pka pKa 2.29±0.009(H2O) (Uncertain)
  • EWG's Food Scores 1
  • FDA UNII 7F64A2K16Z
  • ATC code N05BA17
  • NIST Chemistry Reference Fludiazepam(3900-31-0)
Safety
  • Toxicity :LD50 in mice (mg/kg): 910 orally; 360 i.p.; 1150 s.c. (Asami)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Fludiazepam Chemical Properties,Usage,Production

  • Description Fludiazepam (Item No. 22424) is an analytical reference standard categorized as a benzodiazepine. Fludiazepam is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
  • Originator Erispan,Sumitomo,Japan,1981
  • Uses Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
  • Definition ChEBI: Fludiazepam is a 1,4-benzodiazepinone, an organochlorine compound and an organofluorine compound. It has a role as an anxiolytic drug. It is functionally related to a monofluorobenzene and a diazepam.
  • Manufacturing Process A solution of 60 g of chromic anhydride in 40ml of water was added dropwise to a suspension of 60 g of 2-aminomethyl-1-methyl-5-chloro-3-(ofluorophenyl)- indole hydrochloride in 600 ml of acetic acid. The mixture was stirred at room temperature overnight. To the reaction mixture was added 1.1 liters of ether and 1 liter of water and then 800 ml of 28% ammonium hydroxide, in small portions. The ethereal layer separated, washed with water, dried, and concentrated under reduced pressure. The residue (51.8 g) was dissolved in 100 ml of ethanol, and 100 ml of 20% ethanolic hydrogen chloride was added to the solution and the mixture was cooled. The precipitate was collected by filtration to yield 46.5 g of 1-methyl-7-chloro-5- (o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one hydrochloride, melting point 218°C (decomposed). Recrystallization from ethanol raised the melting point to 218.5°C to 219°C (decomposed).
  • Therapeutic Function Anxiolytic
Fludiazepam Preparation Products And Raw materials
Raw materials
Preparation Products
Fludiazepam Suppliers
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Fludiazepam Spectrum
3900-31-0, FludiazepamRelated Search:
  • 氟地西泮
  • 7-氯-5-(2-氟苯基)-1,3-二氢-1-甲基-2H-1,4-苯并二氮杂卓-2-酮
  • 3900-31-0
  • Bis(N,N-dibutylamine)-N,N’-disulfide-d36
  • Fludiazepam USP/EP/BP
  • 7-chloro-5-(2-fluorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(o-fluorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
  • 1-Methyl-7-chloro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine-2(3H)-one
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-
  • 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-1-methyl-
  • 7-Chloro-5-(2-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
  • Fludiazepan
  • Ro-5-3438
  • ID-540
  • id540
  • Erispan
  • 7-chloro-5-(o-fluorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
  • 7-CHLORO-(2-FLUOROPHENYL)-1,3-DIHYDRO-1-MENTHYL-2H-1,4-BENZODIAZEPIN-2-ONE
  • 7-Chloro-5-(o-Fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
  • 7-chloro-5-(2-fluorophenyl)-1-methyl-1h-1,4-benzodiazepin-2(3h)-one
  • 7-Chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
  • 1,3-dihydro-7-chloro-5-(o-fluorophenyl)-1-methyl-2h-4-benzodiazepin-2-one
  • FLUDIAZEPAM

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