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NEOTROFIN

NEOTROFIN Structure
NEOTROFIN
  • CAS No.192564-13-9
  • Chemical Name:NEOTROFIN
  • CBNumber:CB41011492
  • Molecular Formula:C15H12N5O4.K
  • Formula Weight:365.389
  • MOL File:192564-13-9.mol
NEOTROFIN Property
  • Melting point 268-270°C (dec.)
  • storage temp. Refrigerator
  • solubility Water
  • form Solid
  • color Off White to Pale Yellow
  • FDA UNII Q06WU8JY4F
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

NEOTROFIN Chemical Properties,Usage,Production

  • Chemical Properties Off White to Pale Yellow Solid
  • Uses A synthetic purine derivative with neuroprotective effects. A cognitive enhancer, is transported into brain by a nonsaturable influx mechanism and out of brain by a saturable efflux mechanism.
  • brand name Neotrofin (NeoTherapeutics).
  • in vivo

    Leteprinim (30 or 60 mg/kg, i.p., for 7 days) potassium protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons[1].
    Leteprinim (60 mg/kg, i.p.) potassium enhances working memory in young and aged mice[3].
    Leteprinim (60 mg/kg; i.p.; single dosage) potassium significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups[4].

    Animal Model:Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)[4]
    Dosage:60 mg/kg
    Administration:IP; single dosage
    Result:The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group.
    In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.
NEOTROFIN Preparation Products And Raw materials
Raw materials
Preparation Products
NEOTROFIN Suppliers
Global(26)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
  • ProdList：96815
  • Advantage：76
  • Supplier： Spectrum Chemical Manufacturing Corp.
  • Tel：021-021-021-67601398-809-809-809<br/>15221380277
  • Email：marketing_china@spectrumchemical.com
  • Country：China
  • ProdList：9658
  • Advantage：60
NEOTROFIN Spectrum
192564-13-9, NEOTROFINRelated Search:
  • Pharmaceuticals
  • Nucleotides
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Bases & Related Reagents
  • Heterocycles, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
  • 抑制剂
  • C15H12KN5O4
  • 化合物 LETEPRINIM POTASSIUM
  • 化合物 T32658
  • 192564-13-9
  • Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-, potassium salt (1:1)
  • SPI-205
  • SPI205
  • SPI 205
  • Leteprinim potassium
  • Potassium,4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoate
  • Leteprinim Potassium Salt
  • 4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic Acid Potassium Salt
  • NEOTROFIN
  • 4-{[3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanoyl]amino}benzoic acid

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