SHIONONE

Uses

SHIONONE

SHIONONE Property

Melting point 161-162°
alpha D26.5 -56.1° (c = 1.07 in chloroform)
Boiling point 485.6±14.0 °C(Predicted)
Density 0.941±0.06 g/cm3(Predicted)
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Powder
color White to off-white
optical activity -56.126.5 (c 1.07, CHCl3)
LogP 10.401 (est)
FDA UNII BT0AMD31UB

Safety

Hazard and Precautionary Statements (GHS)

SHIONONE Chemical Properties,Usage,Production

Uses Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections.
Uses Shionone is an effective inhibitor of human neutrophil elastase which may be used as a treatment for inflammatory lung diseases including H1N1 and SARS virus infections.
Definition ChEBI: A tetracyclic triterpenoid that is perhydrochrysene which is substituted by methyl groups at positions 1, 4bbeta, 6aalpha, 8beta, 10abeta and 12a positions, by a 4-methylpent-3-enyl group t the 8alpha position, and with an oxo group at position 2.
in vivo
Shionone (orally administration; 80 mg/kg; 3 days; once daily) shows the trend of enhancing sputum secreting, but has no effect on ammonia-induced cough and reduces xylene-induced ear edema^[1].
Animal Model: ICR male mice^[1]
Dosage: 80 mg/kg
Administration: Orally administration; 3 days; once daily
Result: Reduced the ear edema for 11.3% by use shionone.
target ERK | IkB | NOS | IKK

SHIONONE Preparation Products And Raw materials

Raw materials

Preparation Products

SHIONONE Suppliers

Global(163)Suppliers

SHIONONE Spectrum

10376-48-4, SHIONONERelated Search:

standardized herbal extract
reference standards from Chinese medicinal herbs (TCM).
phytochemical
pharmaceutical intermediate
chemical reagent
萜类
抑制剂
试剂
标准品，对照品
标准品 -中药标准品
三萜
标准品-中药标准品
植物提取物
标准品
中药对照品
对照品
紫菀酮对照品
紫菀酮(标定对照品)
紫菀酮, 来源于紫菀
紫菀酮 20MG
S-HIONONE 紫菀酮
紫苑酮(紫菀酮)
紫菀酮
紫苑酮
10376-48-4
(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methylpent-3-enyl)-1,3,4,4a,5,6,7,9,10,10b,11,12-dodecahydrochrysen-2-one
2(1H)-Chrysenone, hexadecahydro-1,4b,6a,8,10a,12a-hexamethyl-8-(4-methyl-3-penten-1-yl)-, (1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-
Shionon
Shionone, 98%, from Aster tataricus L. f.
21-Shionen-3-one
Shionone ,98%
3β,5,8,17aβ-Tetramethyl-3-(4-methyl-3-pentenyl)-D-homo-5α-androstan-17-one
18,19-Seco-D:A-friedolup-19-en-3-one
hexamethyl-8-(4-methyl-3-pentenyl)-,(1R,4aS,4bS,6aS,8R,10aR,10bS,12aS)-
2(1H)-Chrysenone,hexadecahydro-1,4b,6a,8,10a,12a-
SHIONONE

Animal Model:	ICR male mice^[1]
Dosage:	80 mg/kg
Administration:	Orally administration; 3 days; once daily
Result:	Reduced the ear edema for 11.3% by use shionone.