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KARAKOLINE

KARAKOLINE Structure
KARAKOLINE
  • CAS No.39089-30-0
  • Chemical Name:KARAKOLINE
  • CBNumber:CB3986952
  • Molecular Formula:C22H35NO4
  • Formula Weight:377.52
  • MOL File:39089-30-0.mol
KARAKOLINE Property
  • Melting point 185-186℃ (acetone )
  • Boiling point 540.2±50.0 °C(Predicted)
  • Density 1.30±0.1 g/cm3 (20 ºC 760 Torr)
  • storage temp. 2-8°C
  • form Solid
  • pka 13.80±0.70(Predicted)
  • color White to off-white
Safety
  • RTECS  :AR5569480
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

KARAKOLINE Chemical Properties,Usage,Production

  • Description A second atisine base found in the tubers of Aconitum karacolicum, the structure has been elucidated from chemical and spectroscopic data. Oxidation with KMn04 gives anhydroepoxykaracoline. The alkaloid furnishes a triacetyl deriva_x0002_tive which, after pyrolysis and hydrolysis, yields acetyldemethylisopyrokaracoline.
  • Uses Karacoline is an Aconitane (A189875) derivative, which is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction.
  • Definition ChEBI: An organonitrogen heterocyclic compound that is aconitane bearing hydroxy groups at the 1alpha, 8, and 14alpha positions and substituted at on the nitrogen and at positions 4 and 16beta by ethyl, methyl, a d methoxy groups, respectively.
  • References Sultankhodzhaev, Yunusov, Yunusov., Khim. Prir. Soedin., 9, 199 (1973)
KARAKOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
KARAKOLINE Suppliers
Global(80)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：marketing@targetmol.com
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    TargetMol Chemicals Inc.
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  • Supplier：
    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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KARAKOLINE Spectrum
39089-30-0, KARAKOLINERelated Search:
  • standardized herbal extract
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • chemical reagent
  • Alkaloids
  • 抑制剂
  • 标准品，对照品
  • 标准品 -中药标准品
  • 标准品-中药标准品
  • 植物提取物
  • 植提标准品
  • 中药对照品
  • 对照品
  • 标准品
  • 多根乌头碱,10 MM DMSO 溶液
  • 多根乌头碱(对照品)
  • DGWTJ对照品
  • (1Α,14Α,16Β)-20-乙基-16-甲氧基-4-甲基乌头碱-1,8,14-三醇
  • 多根乌头碱
  • 39089-30-0
  • Karacoline, 10 mM in DMSO
  • Inhibitor,Karacoline,inhibit
  • (1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol
  • 11aH-12,3,6a-Ethanylylidene-7,9-methanonaphth[2,3-b]azocine, aconitane-1,8,14-triolderiv.
  • Carmicheline(7CI)
  • Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-
  • Aconitane-1,8,14-triol,20-ethyl-16-methoxy-4-methyl-, (1a,14a,16b)-
  • Karacoline
  • (16S)-20-Ethyl-16-methoxy-4-methylaconitane-1α,8,14α-triol

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