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9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole

9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole Structure
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole
  • CAS No.10371-86-5
  • Chemical Name:9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole
  • CBNumber:CB3918854
  • Molecular Formula:C18H16N2O
  • Formula Weight:276.33
  • MOL File:10371-86-5.mol
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole Property
  • Melting point 286.5°C (rough estimate)
  • Boiling point 419.24°C (rough estimate)
  • Density 1.1318 (rough estimate)
  • refractive index 1.5700 (estimate)
  • storage temp. -20°C
  • solubility DMSO: soluble
  • form A solid
  • pka 16.29±0.40(Predicted)
  • FDA UNII U0924292N9
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements
  • Precautionary statements

9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole Chemical Properties,Usage,Production

  • Description An Ochrosia alkaloid present in O. oppositifolia and O. sandwicensis Gray, it occurs mainly in the bark of these species. It forms light yellow crystals and gives an ultraviolet spectrum in EtOH with absorption maxima at 242, 275, 290 and 335 mil. It may be characterized as the hydrochloride which has m.p. 288- 290°C following a change in crystal form at 255-265°C, or as the picrate, m.p. 273-5°C. The structure has been elucidated from the mass spectrum fragmentation pattern.
  • Uses SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5[1].
  • Synthesis Reference(s) The Journal of Organic Chemistry, 72, p. 7106, 2007 DOI: 10.1021/jo070774z
  • References Buzas, Osowiecki, Schindler., Cornpt. Rend., 247, 1390 (1958)
    Goodwin, Smith, Horning.,!. Arner. Chern. Soc., 81,1903 (1959)
    Mass spectrum:
    Loder., Austral. J. Chern., 19, 1947 (1966)
    Synthesis:
    Dalton et aI., Austral. J. Chern., 20, 2715 (1967)
9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole Preparation Products And Raw materials
Raw materials
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9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole Suppliers
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9-methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole Spectrum
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