ChemicalBook > CAS DataBase List > platyphylline

platyphylline

platyphylline Structure
platyphylline
  • CAS No.480-78-4
  • Chemical Name:platyphylline
  • CBNumber:CB3914285
  • Molecular Formula:C18H27NO5
  • Formula Weight:337.41
  • MOL File:480-78-4.mol
platyphylline Property
  • Melting point 129°
  • alpha D20 -56.4° (c = 0.7 in chloroform)
  • Boiling point 539.6±50.0 °C(Predicted)
  • Density 1.22±0.1 g/cm3(Predicted)
  • pka 12.83±0.40(Predicted)
  • EWG's Food Scores 1
  • FDA UNII A91172AJBY
Safety
  • RIDADR  :1544
  • HazardClass  :6.1(b)
  • PackingGroup  :III
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

platyphylline Chemical Properties,Usage,Production

  • Description A hepatotoxic alkaloid, the base has been isolated from Senecio adnatus D.C., S. hygrophilus Dyer & Sm. and S. piatyphyllus D.C. The alkaloid is only sparingly soluble in petroleum ether or hot H20, more so in Me2CO, EtOH, C6H6 or Et20 and readily soluble in CHCI3. It is laevorotatory with [α]D - 45.09° (CHCI3). The perchlorate occurs as colourless prisms from H20, m.p. 222-3°C (dec.); the picrolonate, dark yellow needles, m.p. 205-6°C (dec.); aurichloride, m.p. 200-loC (dec.) and the methiodide, m.p. 216-7°C; [α]D - 31.27° (EtOH). The alkaloid contains one hydroxyl group but no methoxyl or methylimino groups. On hydrolysis it furnishes platynecine, CSH1S0 2N, m.p. 148°C; [α]D - 56.8° (CHCI3) and platynecic acid, ClOH140 4 , m.p. l54-5°C which is identical with senecic acid lactone.
  • Uses 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione is a pyrrolizidine alkaloid which can be found in various Senecio species. It can be useful in the generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine .
  • Definition ChEBI: Platyphylline is a macrolide.
  • References Orekhov, Tiedebel., Ber., 68,653 (1935)
    Orekhov, Konovalova, Tiedebel., ibid, 68, 1886 (1935)
    Orekhov, Tiedebel., J. Gen. Chern. USSR, 8,273 (1938)
    de Waal., Onderstepoort J., 15,251 (1940)
    Koekemoer, Warren., J. Chern. Soc., 63 (1955)
platyphylline Preparation Products And Raw materials
Raw materials
Preparation Products
platyphylline Suppliers
Global(24)Suppliers
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15393
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38636
  • Advantage：58
  • Supplier：
    GIHI CHEMICALS CO.,LIMITED
  • Tel： +8618058761490
  • Email：info@gihichemicals.com
  • Country：China
  • ProdList：49984
  • Advantage：58
  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
  • ProdList：96815
  • Advantage：76
  • Supplier： EMMX Biotechnology LLC
  • Tel：888-539-0666
  • Email：info@emmx.com
  • Country：United States
  • ProdList：8447
  • Advantage：60
platyphylline Spectrum
480-78-4, platyphyllineRelated Search:
  • 中药对照品
  • 阔叶千里光碱
  • 闊葉千里光鹼
  • 480-78-4
  • PLATYPHYLLINI HYDROTARTRAS
  • [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidenedodecahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,9aS,14aR,14bR)-
  • Platyphyllin
  • 12-Hydroxy-1,2-dihydrosenecionan-11,16-dione
  • Senecionan-11,16-dione, 1,2-dihydro-12-hydroxy-, (1-alpha)-
  • Platiphyllin
  • Platiphillin
  • Einecs 207-558-6
  • 66641-38-1 (Hydrochloride)
  • (1-alpha)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
  • Platifillin
  • [1R,(-)]-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
  • (1R)-1,2-Dihydro-12-hydroxysenecionan-11,16-dione
  • platyphylline

Home

My