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3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate

CAS No.23930-37-2
Chemical Name:3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate
CBNumber:CB3884676
Molecular Formula:C23H34O5
Formula Weight:390.51306
MOL File:23930-37-2.mol

3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Property

Melting point 175-177°
alpha D26 +97° (c = 1.02 in chloroform)
Boiling point 523.6±50.0 °C(Predicted)
Density 1.164±0.06 g/cm3(Predicted)
pka 15.04±0.70(Predicted)
form Solid
color White to off-white
FDA UNII 00TN4GS00S

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
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Precautionary statements

3alpha,21-dihydroxy-5alpha-pregnane-11,20-dione 21-acetate Chemical Properties,Usage,Production

Uses Alphadolone acetate (Alfadolone acetate) is a steroid agent that can suppress or relieve pain, with antinociception[1].
Definition ChEBI: Acetic acid [2-[(3R,5S,8S,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-11-oxo-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] ester is a corticosteroid hormone.

in vivo

Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet^[2].
Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats^[3].

Animal Model:	Inbred Wistar-derived colony female rats (intramuscularly injected with 20 μg/100g oestradiol benzoate)^[2]
Dosage:	Anaesthetized with a 3 :1 mixture of Alphaxalone and Alphadolone acetate
Administration:	i.m.
Result:	Blocked the oestrogen-stimulated LH surge and impairs pulsatile secretion.

Animal Model:	Male Sprague-Dawley rats (orchidectomized; aged 90-120 days and weighing 300-350 g)^[3]
Dosage:	14 mL/kg
Administration:	i.p.; single dosage
Result:	Decreased serum concentrations of LH.

References [1] Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Pain. 2000 Oct;88(1):31-39. DOI:10.1016/S0304-3959(00)00300-6
[2] Dyer RG, Mansfield S. Anaesthesia with alphaxalone plus alphadolone acetate blocks the oestrogen-stimulated LH surge and impairs pulsatile LH secretion in ovariectomized female rats. J Endocrinol. 1984 Jul;102(1):27-31. DOI:10.1677/joe.0.1020027
[3] Emanuele MA, et al. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov;115(2):221-3. DOI:10.1677/joe.0.1150221