Tallimustine

Uses

Tallimustine (FCE 24517), a distamycin-A derivative, is an anticancer agent[1][2][4].

in vivo

References

[1] Herzig MC, et al. Tallimustine lesions in cellular DNA are AT sequence-specific but not region-specific. Biochemistry. 1999 Oct 19;38(42):14045-55. DOI:10.1021/bi991286r
[2] Bianchi N, et al. Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine. Br J Haematol. 2001 Jun;113(4):951-61. DOI:10.1046/j.1365-2141.2001.02843.x
[3] Erba E, et al. Comparison of cell-cycle phase perturbations induced by the DNA-minor-groove alkylator tallimustine and by melphalan in the SW626 cell line. Int J Cancer. 1995 Jul 17;62(2):170-5. DOI:10.1002/ijc.2910620211
[4] Tagliabue G, et al. Combination of the new minor groove alkylator tallimustine and melphalan. Eur J Cancer. 1997 Feb;33(2):284-7. DOI:10.1016/s0959-8049(96)00435-2