Synthesis
ChemicalBook > CAS DataBase List > 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

Synthesis
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Structure
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • CAS No.120014-07-5
  • Chemical Name:1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • CBNumber:CB3854945
  • Molecular Formula:C24H27NO3
  • Formula Weight:377.48
  • MOL File:120014-07-5.mol
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Property
  • Melting point 176-178°C
  • Boiling point 542.8±50.0 °C(Predicted)
  • Density 1.209±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,Room Temperature
  • pka 8.03±0.10(Predicted)
Safety
  • HS Code  :2933399990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319
  • Precautionary statements P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Chemical Properties,Usage,Production

  • Synthesis A solution of 5,6-dimethoxy-indanone (19 g, 0.10 mol) in methanol (8 mL) is stirred under inert atmosphere at room temperature. Slowly add NaOH flakes (12.8 g, 0.32 mol) followed by N-benzyl-piperidine-4-carboxaldehyde (20.2 g, 0.10 mol) to the reaction mixture. The mixture was stirred at room temperature for 3 h and progress of the reaction was monitored by TLC (hexane:ethyl acetate; 1:1). Once the reaction is complete, the solid formed was filtered, washed with 5 % acetic acid and then with methanol and dried. The obtained solid (34 g) was taken into a round bottom flask and refluxed with DMF (50 mL). Gradually cooled to room temperature and stirred for 2 h, filtered the solid formed, wash with chilled methanol to afford a pale yellow crystalline solid 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine (32.0 g, 84 %); m.p.: 175-177 °C.
  • Uses An impurity of Donepezil; an intermediate as an anti-Alzheimer agent.
  • Uses An impurity of Donepezil (D531750); an intermediate as an anti-Alzheimer's agent.
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Spectrum
120014-07-5, 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidineRelated Search:
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  • Intermediates & Fine Chemicals
  • Intermediates
  • Heterocycles
  • Aromatics
  • 杂质对照品
  • 标准品
  • C24H27NO3
  • RSYY(阿哌沙班)-42
  • 2-((1-苯甲基哌啶-4-基)亚甲基)-5,6-二甲氧基-2,3-二氢-1H-茚-1-酮
  • 多奈哌齐相关化合物
  • 多奈哌齐标准品3-Z
  • 多奈哌齐相关化合物(E/Z混合物)
  • 多奈哌齐标准品013
  • 多奈哌齐杂质;1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶
  • 2-((1-苄基哌啶-4-基)亚甲基)-5,6-二甲氧基-2,3-二氢-1H-茚-1-酮
  • 多奈哌齐美国药典相关化合物 A
  • 脱氢多奈哌齐
  • 1-BENZYL-4-[(5,6-DIMETHOXY-1-OXOINDAN-2-YLIDENE)METHYL]PIPERIDINE[干冰运输]
  • 1-苄基-4-(5,6-二甲氧基-1-茚酮-2-亚甲基)哌啶
  • 1-苄基-4-[(5,6-二甲氧基-1-茚酮)-2-次甲基]-哌啶
  • 盐酸多奈哌齐USP相关物质A
  • 1 - 苄基-4 - [(5,6 - 二甲氧基-1-氧茚2 - 亚基)甲基]哌啶
  • 多奈哌齐相关物质
  • 120014-07-5
  • (Z)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  • (E)-1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • Donepezil Dehydro Impurity (E/Z mixture)
  • 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperi...
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine DISCONTINUED. Please see D229775
  • 2-[(1-Benzylpiperidin-4-yl)methylen
  • Donepezil Impurity 17
  • Donepezil-013-Z
  • Donepezil Impurity O
  • Donepezil related compound
  • Donepezil impurity 16/1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • Donepezil-013
  • 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97%
  • 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  • 2-[(1-benzyl-4-piperidyl)methyleen]-5,6-dimethoxyindan-1-on
  • 1-benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
  • Dehydro Donepezil
  • (E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
  • 1H-Inden-1-one, 2,3-dihydro- 5,6-diMethoxy-2-[[1-( phenylMethyl)-4-piperidinyl] Methylene]-
  • Donepezil related coMpound (E/Z Mixture)
  • 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one
  • 1-Benzyl-4-[(1,3-dihydro-5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]piperidine
  • Donepezil USP RC A
  • Dehydro Donepezi
  • 1-Benzyl-4-(5,6-diMethoxy-1-oxoindan-2-ylindeneMet
  • 1-Benzyl-4-[(5,6-diMethoxy-1-oxoindan-2-ylidene)Methyl]piperidine (Donepezil IMpurity)
  • 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one
  • Dehydro Donepezil (Donepezil Impurity)
  • 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one
  • 2-(1-Benzylpiperidin-4-ylmethylidene)-5,6-dimethoxyindan-1-one
  • 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
  • 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-
  • 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE

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