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DIBUTYLCARBAMYL CHLORIDE

DIBUTYLCARBAMYL CHLORIDE Structure
DIBUTYLCARBAMYL CHLORIDE
  • CAS No.13358-73-1
  • Chemical Name:DIBUTYLCARBAMYL CHLORIDE
  • CBNumber:CB3783443
  • Molecular Formula:C9H18ClNO
  • Formula Weight:191.7
  • MOL File:13358-73-1.mol
DIBUTYLCARBAMYL CHLORIDE Property
  • Boiling point 257-260 °C(lit.)
  • Density 0.985 g/mL at 25 °C(lit.)
  • refractive index n20/D 1.456(lit.)
  • Flash point 110 °C
  • pka -1.85±0.70(Predicted)
  • EWG's Food Scores 1
Safety
  • Hazard Codes  :C
  • Risk Statements  :34
  • Safety Statements  :26-36/37/39-45
  • RIDADR  :UN 3265 8/PG 3
  • WGK Germany  :3
  • RTECS  :FD2230000
  • HazardClass  :IRRITANT
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H314
  • Precautionary statements P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501

DIBUTYLCARBAMYL CHLORIDE Chemical Properties,Usage,Production

  • Uses It is reported that Dibutylcarbamoyl Chloride is used as a reagent for the preparation of 7-azaindole-1,3-dicarboxamide hydroxyethylamine which exhibited potent BACE-1 enzyme inhibition. Also it is used for the preparation of copper salicylaldehyde semicarbazone complex which showed cytotoxicity in human cancer cells.
  • Preparation In a 100 mL roundbottomed flask were placed dibutylamine (6.45 g, 0.05 mol), pyridine (4.0 g, 0.05 mol), N-cyclohexyl-N0,N0,N00,N00-tetraethylguanidine (12.7 g, 0.05 mol), and toluene (40 mL). The resulting solution was cooled to 10 °C using an ice/salt bath and carbon dioxide was bubbled into the cooled solution for 30 min. After this period of time, the pre-formed carbamate solution was added in a single portion via a cannula to a cooled ( 10 °C) solution of thionyl chloride (6 g, 0.05 mol) in toluene (40 mL). The reaction mixture was stirred at 10 °C for 45 min. It was then poured into 0.1 m aq. HCl (100 mL), giving rise to two layers. The organic layer was separated, dried over anhydrous Mg2SO4, filtered, and the solvent was removed in vacuo. The residue was distilled in vacuo (1 mmHg) at 95–98 °C to give 7.62 g (79%) of N,N-dibutyl carbamoyl chloride.
DIBUTYLCARBAMYL CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
DIBUTYLCARBAMYL CHLORIDE Suppliers
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DIBUTYLCARBAMYL CHLORIDE Spectrum
13358-73-1, DIBUTYLCARBAMYL CHLORIDERelated Search:
  • Organic Building Blocks
  • Carbonyl Compounds
  • Acid Halides
  • Acid Halides
  • Organic Building Blocks
  • Building Blocks
  • Carbonyl Compounds
  • CH3CH232NCOCl
  • N,N-二正丁基-氯甲酰胺
  • 二丁基甲氨酰氯
  • 二丁基氨基甲酰氯化物
  • 氨基甲酰氯化物,二丁基-
  • 氨基甲酰氯,1,6-二丁基-
  • 二丁基氨基甲酰氯
  • 13358-73-1
  • DIBUTYLCARBAMYL CHLORIDE ISO 9001：2015 REACH
  • Carbamic chloride, N,N-dibutyl-
  • dibutylcarbamic chloride
  • Einecs 236-410-3
  • Carbamoyl chloride, dibutyl-
  • Carbamic chloride, 1,6-dibutyl-
  • Brn 2040828
  • Dibutylcarbamic acid chloride
  • N,N-dibutylcarbamoyl chloride
  • tl459
  • dibutylcarbamoylchloride
  • dibutyl-carbamoylchlorid
  • 1,6-dibutyl-carbamicchlorid
  • DIBUTYLCARBAMYL CHLORIDE

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