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1-ADAMANTANAMINE SULFATE

1-ADAMANTANAMINE SULFATE Structure
1-ADAMANTANAMINE SULFATE
  • CAS No.31377-23-8
  • Chemical Name:1-ADAMANTANAMINE SULFATE
  • CBNumber:CB3735518
  • Molecular Formula:C10H19NO4S
  • Formula Weight:249.33
  • MOL File:31377-23-8.mol
1-ADAMANTANAMINE SULFATE Property
  • Melting point 300 °C
  • storage temp. Store below +30°C.
  • solubility Aqueous Acid (Slightly), Aqueous Base (Slightly)
  • form Fine Crystalline Powder
  • color White
  • PH 4.9 (100g/l, H2O, 20°C) (slurry)
  • Stability Hygroscopic
  • InChIKey MYWTWSQFJLXGGQ-JUMAMQMDSA-N
  • CAS DataBase Reference 31377-23-8(CAS DataBase Reference)
  • FDA UNII 9921T5P019
  • UNSPSC Code 12352107
  • NACRES NA.22
Safety
  • Safety Statements  :24/25
  • WGK Germany  :WGK 3 highly water endangering
  • HS Code  :2921 30 99
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
1-ADAMANTANAMINE SULFATE Price More Price(1)
  • Brand: TCI Chemicals (India)
  • Product number: A1319
  • Product name : 1-Adamantanamine Sulfate
  • Purity: 
  • Packaging: 25G
  • Price: ₹4600
  • Updated: 2022/05/26
  • Buy: Buy

1-ADAMANTANAMINE SULFATE Chemical Properties,Usage,Production

  • Chemical Properties white fine crystalline powder
  • Uses Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].
  • Definition ChEBI: An alkylammonium sulfate salt obtained by combining amantadine and sulfuric acid in a 2:1 ratio. Used as an antiviral and antiparkinson drug.
  • in vivo

    Amantadine sulfate (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment[5].

    Animal Model:Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)[5]
    Dosage:25 mg/kg
    Administration:IP, once daily for 3 days (the first dose at 15 min before surgery)
    Result:Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
  • IC 50 CDK2; Bcl-2; Bax
  • References [1] Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. DOI:10.1007/s10156-003-0262-6
    [2] Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. DOI:10.1212/WNL.0b013e31824e8f0d
    [3] Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. DOI:10.1016/s0166-3542(02)00199-7
    [4] Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. DOI:10.3390/v13040539
    [5] Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. DOI:10.1097/ALN.0000000000000352
    [6] Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. DOI:10.3892/ijmm.2015.2289
1-ADAMANTANAMINE SULFATE Preparation Products And Raw materials
Raw materials
Preparation Products
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1-ADAMANTANAMINE SULFATE Spectrum
31377-23-8, 1-ADAMANTANAMINE SULFATERelated Search:
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  • 31377-23-8
  • 1-ADAMANTANAMINE SULFATE ISO 9001：2015 REACH
  • antadine
  • 1-Adamantanamine Sulfate &gt
  • 1-Adamantylamine sulphate
  • 1-ADAMANTAMINE SULFATE
  • Adamantan-1-amine sulfate
  • AMANTADINE SULFATE FOR SYNTHESIS
  • 1-Adamantanamine sulfate,99%
  • Adamantan-1-amine sulphate
  • amantadine sulphate (INNM)
  • TRICYCLO[3.3.1.13.7]DECAN-1-AMINE SULFATE (AMANTADINE SULFATE)
  • AMANTADINE SULPHATE
  • AMANTADINE SULFATE
  • ADAMANTYLAMINE SULFATE
  • 1-ADAMANTANANAMINE SULPHATE
  • 1-ADAMANTANAMINE SULPHATE
  • 1-ADAMANTANAMINE SULFATE
  • 1-AMINOADAMANTANSULFATE
  • 1-AMINOADAMANTANE SULPHATE
  • 1-AMINOADAMANTANE SULFATE
  • 1-Adamantylamine sulfate
  • AMANTADINE SULFATE 99+%

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