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2,4-Dichloropyrido[2,3-d]pyrimidine

2,4-Dichloropyrido[2,3-d]pyrimidine Structure
2,4-Dichloropyrido[2,3-d]pyrimidine
  • CAS No.126728-20-9
  • Chemical Name:2,4-Dichloropyrido[2,3-d]pyrimidine
  • CBNumber:CB3696084
  • Molecular Formula:C7H3Cl2N3
  • Formula Weight:200.02
  • MOL File:126728-20-9.mol
2,4-Dichloropyrido[2,3-d]pyrimidine Property
  • Melting point 157-158 °C (decomp)
  • Density 1.573±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • pka -0.38±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501

2,4-Dichloropyrido[2,3-d]pyrimidine Chemical Properties,Usage,Production

  • Reactivity Profile Selective disubstitution of 2,4-dichloropyrido[2,3-d]pyrimidine with various nucleophiles was investigated by Lavecchia et al. Suzuki and Stille cross-coupling reactions on monosubstituted compound 4-tert-butylamino-2-chloro-pyrido[2,3-d]pyrimidine were performed in high yields. ,4-dichloropyrido[2,3-d]pyrimidine was easily substituted at position 4 with different nucleophiles. This position was more reactive than position 2, as in simple pyrimidinic systems. 2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method.
    2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
  • Synthesis 2,4-dichloropyrido[2,3-d]pyrimidine 3 was prepared from 2-aminonicotinic acid 1 via 2,4-dihydroxypyrido[2,3-d]pyrimidine 2 following Robin and Hitchings method[1].
    2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
  • References [1] G. Lavecchia, G. Guillaumet, S. Berteina-Raboin. “Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions.” Tetrahedron Letters 46 35 (2005): Pages 5851-5855.
2,4-Dichloropyrido[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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2,4-Dichloropyrido[2,3-d]pyrimidine Spectrum
126728-20-9, 2,4-Dichloropyrido[2,3-d]pyrimidineRelated Search:
  • 化工中间体
  • 医用原料
  • 高端化学
  • 化工原料
  • 合成材料中间体
  • 有机化学
  • C7H3Cl2N3
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  • 126728-20-9
  • 2,4-Dichloro-pyrido[2,3-d]pyrimidine2,4-Dichloro-pyrido[2,3-d]pyrimidine
  • 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
  • Pyrido[2,3-d]pyrimidine,2,4-dichloro-
  • 2,4-dichloropyrido[2,3-d]...

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