CHLORPHENOXAMINE HYDROCHLORIDE (200 MG)

Originator

Phenoxene ,Dow ,US ,1959

Uses

Chlorphenoxamine Hydrochloride is an antihistaminic preparation used as a treatment for antibacterial infections.Chlorphenoxamine Hydrochloride is also used in the pharmaceutical compositions for treating coronavirus infection.

Manufacturing Process

A Grignard solution is prepared by introducing methyl chloride into a boiling suspension of 36 g of magnesium in 1,000 cc of absolute ether until all the magnesium has reacted. 216 grams of 4-chloro-benzophenone are slowly added to the Grignard solution with ice cooling and stirring; after 15 hours, the thus-obtained product is poured into a mixture of 200 g of ammonium chloride and ice, whereupon it is separated with ether. The separated ether layer is dried with sodium sulfate, and the ether is distilled. The residual carbinol is added to a suspension of 45 g of sodium amide in 500 cc of toluene. To the thus-obtained mixture there are added 125 g of dimethylaminoethyl chloride, and the mixture is heated at boiling temperature for 3 hours with stirring.
The mixture is taken up with water and the base is extracted from the toluene with dilute hydrochloric acid. The hydrochloric solution is rendered alkaline with caustic soda, the base is separated with ether, dried, and after distillation of the ether fractionated in vacuo, BP at 0.05 mm Hg, 150° to 153°C. The basic ether is then dissolved in dry ether, and ether saturated with dry hydrogen chloride is added dropwise with stirring. An excess of hydrogen chloride must be avoided as it may produce decomposition to the corresponding diphenyl ethylene. The ether-moist hydrochloride is preferably dried at once in vacuo and subsequently reprecipitated from acetone-ether and then again dried in vacuo over phosphorus pentoxide. Hydrochloride, MP 128°C.

brand name

Phenoxene (Marion Merrell Dow).

Therapeutic Function

Muscle relaxant; Antiparkinsonian