Synthesis
4-Bromobenzenesulfonyl chloride (5.00 g, 19.69 mmol) and bromobenzene (4.61 g, 29.54 mmol) were added to a 250 mL three-necked flask and dissolved in 40 mL of dichloromethane. Ferric chloride (6.34 g, 39.39 mmol) was then added and the reaction mixture was heated to 40 °C and stirred for 6 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and 30 mL of dichloromethane and 50 mL of 1 M hydrochloric acid solution were slowly added and stirring was continued for 10 minutes. The mixture was transferred to a partition funnel and the organic layer was separated. The aqueous layer was extracted three times with dichloromethane and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated by rotary evaporation to obtain the crude product. The crude product was purified by silica gel column chromatography, and the eluent was a solvent mixture of hexane and dichloromethane (4:5, v/v). The final product was dried under vacuum to give 4,4'-dibromodiphenyl sulfone (6.48 g, 88% yield) in white powder form.
References
[1] Patent: CN108084150, 2018, A. Location in patent: Paragraph 0086; 0087; 0088; 0089
[2] Recueil des Travaux Chimiques des Pays-Bas, 1910, vol. 29, p. 324
[3] Recueil des Travaux Chimiques des Pays-Bas, 1911, vol. 30, p. 139
[4] Recueil des Travaux Chimiques des Pays-Bas, 1914, vol. 33, p. 130,152
[5] Chem. Zentralbl., 1914, vol. 85, # I, p. 2166
