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NEMONAPRIDE

NEMONAPRIDE Structure
NEMONAPRIDE
  • CAS No.75272-39-8
  • Chemical Name:NEMONAPRIDE
  • CBNumber:CB3492220
  • Molecular Formula:C21H26ClN3O2
  • Formula Weight:387.9
  • MOL File:75272-39-8.mol
NEMONAPRIDE Property
  • Melting point 152-153°C
  • storage temp. Store at RT
  • solubility Chloroform (Slightly), Methanol (Slightly)
  • form Solid
  • color White to Off-White
  • CAS DataBase Reference 75272-39-8
  • FDA UNII Q88T5P3444
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501

NEMONAPRIDE Chemical Properties,Usage,Production

  • Description Nemonapride is a potent dopamine D2receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.
  • Description Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D2)-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT1A; IC50 = 34 nM).
  • Chemical Properties Colourless Crystalline Solid
  • Originator Yamanouchi (Japan)
  • Uses Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.
  • Uses A selective dopamine D2 receptor antagonist. Used as an antipsychotic
  • Definition ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride.
  • brand name Emirace
  • Biological Activity Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.
  • storage Store at RT
NEMONAPRIDE Preparation Products And Raw materials
Raw materials
Preparation Products
NEMONAPRIDE Suppliers
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NEMONAPRIDE Spectrum
75272-39-8, NEMONAPRIDERelated Search:
  • Dopamine receptor
  • Pharmaceuticals
  • Neurochemicals
  • Intermediates & Fine Chemicals
  • Heterocyclic Compounds
  • Heterocycles
  • Aromatics
  • 抑制剂
  • 中枢神经系统用药
  • 药物
  • 精神病治疗药
  • C21H26Cl23O2
  • 化合物 NEMONAPRIDE
  • 化合物 T23063
  • 顺-5-氯-2-甲氧基-4-(甲基氨基)-N-[2-甲基-2-(苯基甲基)-3-吡咯烷基]苯甲酰胺
  • 75272-39-8
  • N-(Cis-1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide
  • (2R,3R)-nemonapride
  • cis-5-Chloro-2-methoxy-4-(methylamino)-N-[2-methyl-2-(phenylmethyl)-3-pyrrolidinyl]benzamide
  • rel-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[(2R,3R)-2-Methyl-1-(phennylMethyl)-3-pyrrolidinyl]benzaMide
  • cis-5-Chloro-2-Methoxy-4-(MethylaMino)-N-[2-Methyl-1- (phennylMethyl)-3-pyrrolidinyl]benzaMide
  • C12915
  • N-[(2R,3R)-1-Benzyl-2-methylpyrrolidine-3-yl]-2-methoxy-4-(methylamino)-5-chlorobenzamide
  • YM 09151-2
  • Emilace
  • Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, cis-
  • Benzamide, 5-chloro-2-methoxy-4-(methylamino)-N-[(2R,3R)-2-methyl-1-(phenylmethyl)-3-pyrrolidinyl]-, rel- (9CI)
  • ym-09151
  • nobenzamide
  • n-(2rs,3rs)-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-2-methoxy-4-methylam
  • inobenzamide
  • emonapride
  • cis-(+-)-rrolidinyl)
  • benzamide,5-chloro-2-methoxy-4-(methylamino)-n-(2-methyl-1-(phenylmethyl)-3-py
  • (+-)-cis-n-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylami
  • NEMONAPRIDE
  • REL-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[(2R,3R)-2-METHYL-2-(PHENNYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE
  • CIS-5-CHLORO-2-METHOXY-4-(METHYLAMINO)-N-[2-METHYL-1-(PHENYLMETHYL)-3-PYRROLIDINYL]BENZAMIDE

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