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SCOPARONE

CAS No.120-08-1
Chemical Name:SCOPARONE
CBNumber:CB3486326
Molecular Formula:C11H10O4
Formula Weight:206.19
MOL File:120-08-1.mol

SCOPARONE Property

Melting point 143-145 °C (lit.)
Boiling point 265.04°C (rough estimate)
Density 1.0858 (rough estimate)
refractive index 1.4389 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility >8.4mg/mL in DMSO
form Powder
color Light yellow to yellow
Merck 13,8479
LogP 1.331 (est)
CAS DataBase Reference 120-08-1(CAS DataBase Reference)
FDA UNII H5841PDT4Y
NIST Chemistry Reference 2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn
Risk Statements :23/24/25-36-22
Safety Statements :27/28-36/37/39-45-26
RIDADR :2811
WGK Germany :3
RTECS :GN6550000
HazardClass :6.1(b)
PackingGroup :III
HS Code :29322090

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H301-H319
Precautionary statements P301+P310+P330-P305+P351+P338

SCOPARONE Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: 254886
Product name : 6,7-Dimethoxycoumarin
Purity: 98%
Packaging: 250MG
Price: ₹11019.85
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 254886
Product name : 6,7-Dimethoxycoumarin
Purity: 98%
Packaging: 1G
Price: ₹29303.28
Updated: 2022/06/14
Buy: Buy

SCOPARONE Chemical Properties,Usage,Production

Uses Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis.
Definition ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin.
Synthesis Reference(s) Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859
General Description 6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.
Safety Profile Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. An anthypertensive agent. When heated to decomposition it emits acrid smoke and irritating fumes.