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CONGLOBATIN

CONGLOBATIN Structure
CONGLOBATIN
  • CAS No.72263-05-9
  • Chemical Name:CONGLOBATIN
  • CBNumber:CB3460272
  • Molecular Formula:C28H38N2O6
  • Formula Weight:498.61
  • MOL File:72263-05-9.mol
CONGLOBATIN Property
  • Density 1.060±0.06 g/cm3 (20 ºC 760 Torr)
  • storage temp. -20°C
  • solubility DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
  • form White to off-white solid.
  • color White to off-white
  • UNSPSC Code 12352205
  • NACRES NA.25
Safety
  • WGK Germany  :3
  • HS Code  :29419000
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
CONGLOBATIN Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SMB00017
  • Product name : Conglobatin
  • Purity: ≥90% (LC/MS-ELSD)
  • Packaging: 1MG
  • Price: ₹33828.13
  • Updated: 2022/06/14
  • Buy: Buy

CONGLOBATIN Chemical Properties,Usage,Production

  • Uses Conglobatin is a macrolide dilactone from Streptomyces. It exhibits anticancer and immunosuppressant properties.
  • Uses Isolated from Streptomyces conglobatus, conglobatin has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups. Conglobatin exhibits an IC50 of 0.63 μg/ml in a NFAT-dependant transcription assay. No toxicity was observed at doses up to 1000 mg/kg when administered to mice either orally or interperitoneally.
  • in vivo

    Conglobatin (50-200 mg/kg; i.g. q3d for 24 d) inhibits the tumor growth of SKBR3 and MCF-7 human breast cancer xenograft models in a dose-dependent manner[2].
    Conglobatin (4-8 mg/kg; i.p. daily for 21 days) inhibits tumor growth in EC109 and KYSE510 tumor xenograft models with low toxicity[3]

    Animal Model:BALB/c (nu/nu) athymic mice with SKBR3 and MCF-7 tumor xenograft[2]
    Dosage:50, 100, 200 mg/kg
    Administration:Oral gavage every 3 days for 24 days
    Result:Showed inhibition of tumor growth at a rate of 39.1%, 52.7%, and 67.5% in the SKBR3 cell line groups and 27.3%, 39.8%, 54.3% in the MCF-7 cell line groups at the three increasing doses, respectively.
    Was well tolerated.
  • IC 50 HSP90
CONGLOBATIN Preparation Products And Raw materials
Raw materials
Preparation Products
CONGLOBATIN Suppliers
Global(43)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32200
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：52924
  • Advantage：58
  • Supplier：
    Pure Research Chemicals
  • Tel：13564847951<br/>18019592524
  • Email：info@purerechem.com
  • Country：China
  • ProdList：967
  • Advantage：58
  • Supplier： Lancrix Chemicals
  • Tel：86-21-50817262
  • Email：sales@lancrix.com
  • Country：China
  • ProdList：1502
  • Advantage：55
CONGLOBATIN Spectrum
72263-05-9, CONGLOBATINRelated Search:
  • Antibiotic
  • 抑制剂
  • 微生物代谢物
  • 丛洛巴汀
  • 成球菌素
  • 72263-05-9
  • Conglobatin (FW-04-806)
  • NGLOBATIN
  • (3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis[(1,3-oxazol-5-yl)methyl]-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione
  • Conglobactin
  • 1,9-Dioxacyclohexadeca-3,11-diene-2,10-dione, 3,5,7,11,13,15-hexamethyl-8,16-bis(5-oxazolylmethyl)-, (3E,5R,7S,8S,11E,13R,15S,16S)-
  • Conglobatin, >=99%
  • CONGLOBATIN
  • FW-04-806
  • (3E,5R,7S,8S,11E,13R,15S,16S)-3,5,7,11,13,15-Hexamethyl-8,16-bis(5-oxazolylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione

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