Description
1,2-
Dioleoyl-
sn-
glycerol is an analog of the protein kinase C-
activating second messenger DAG. 1,2-
Dioleoyl-
sn-
glycerol and 1,2-
dioctanoyl-
sn-
glycerol are nearly equipotent in induction of the acrosome reaction in human sperm.
Uses
1,2-Dioleoyl-sn-glycerol is an analog of 1,3-Dioleoylglycerol (D4842100 which is used in the synthesis of amphiphilic gadolinium complexes as MRI contrast agents.
Uses
18:1 DG may be used:
- in the lipid-protein overlay screen assay with Arabidopsis Rho-like GTPases recombinant protein and Arabidopsis plasma membrane H+-ATPase
- in the preparation of the Golgi-like liposomes
- in giant unilamellar vesicles (GUVs) preparation
Definition
ChEBI: A 1,2-diacyl-sn-glycerol in which the acyl groups at positions 1 and 2 are specified as oleoyl.
General Description
Diacylglycerol/diglyceride (DAG) is a glycerolipid, that is located at the plasma membrane. It is made up of two fatty acid chains that are covalently attached to a single glycerol molecule with the help of an ester linkage.
Biochem/physiol Actions
18:1 DG or 1,2-dioleoyl-sn-glycerol (DOG) fails to prevent the late fission events in the Golgi membrane. DOG is used in ferrihaem π–π tetramer aggregate preparation and β-haematin production.
References
[1] CAROLYN MAUD DOHERTY. Characterization of Two Second Messenger Pathways and Their Interactions in Eliciting the Human Sperm Acrosome Reaction[J]. Journal of andrology, 1995, 16 1: 36-46. DOI:
10.1002/j.1939-4640.1995.tb01728.x
