ChemicalBook > CAS DataBase List > K-252B

K-252B

K-252B Structure
K-252B
  • CAS No.99570-78-2
  • Chemical Name:K-252B
  • CBNumber:CB3452783
  • Molecular Formula:C26H19N3O5
  • Formula Weight:453.45
  • MOL File:99570-78-2.mol
K-252B Property
  • Boiling point 769.8±60.0 °C(Predicted)
  • Density 1.78±0.1 g/cm3(Predicted)
  • storage temp. −20°C
  • solubility Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 1 mg/ml).
  • form ready-to-use solution
  • pka 3.33±0.40(Predicted)
  • color White or off-white
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
Safety
  • Hazard Codes  :Xi
  • RIDADR  :UN 1993 / PGIII
  • HS Code  :29349990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

K-252B Chemical Properties,Usage,Production

  • Description K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC50 = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.
  • Chemical Properties Yellow solid
  • Uses K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).
  • Uses K 252b, is an antibiotics, and a known protein tyrosine kinase inhibitor. It has been also shown to inhibit the trophic activity of brain-derived neurotrophic factor on dopaminergic (DAergic) neurons and nerve growth factor on basal forebrain cholinergic neurons.
  • References 1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Makino et al. (2012), Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling; PLoS One, 7 e41049
K-252B Preparation Products And Raw materials
Raw materials
Preparation Products
K-252B Suppliers
Global(113)Suppliers
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32222
  • Advantage：58
  • Supplier：
    Aladdin Scientific
  • Tel：
  • Email：tp@aladdinsci.com
  • Country：United States
  • ProdList：57505
  • Advantage：58
  • Supplier： J & K SCIENTIFIC LTD.
  • Tel： 18210857532
  • Email：jkinfo@jkchemical.com
  • Country：China
  • ProdList：96815
  • Advantage：76
  • Supplier：
  • Tel：821-50328103-801<br/>18930552037
  • Email：3bsc@sina.com
  • Country：China
  • ProdList：15839
  • Advantage：69
K-252B Spectrum
99570-78-2, K-252BRelated Search:
  • Protein Kinase
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase C (PKC)
  • Antibiotics A to
  • Antibiotics
  • Antibiotics G-MSerine/Threonine Kinase Biology
  • antibiotic
  • 抑制剂
  • 化工原料
  • 生化试剂
  • 微生物代谢物
  • 抗生素
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics G-M
  • BioChemical
  • K-252B |CAS 99570-78-2
  • 蛋白激酶抑制剂 K-252B
  • 化合物 K-252B
  • K252B,蛋白激酶抑制剂
  • 蛋白激酶仰制剂 K-252B
  • 99570-78-2
  • (5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylic acid
  • 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, (9S,10R,12R)-
  • (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
  • K252b Antibiotic K 252b KT 5556
  • KT 5556
  • Antibiotic K 252b
  • k-252b solution
  • K252B READY MADE
  • K-252B, NOCARDIOPSIS SPECIES
  • K-252B, NOCARDIOPSIS SP
  • K-252B
  • PROTEIN KINASE INHIBITOR K-252B

Home

My