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Ifenprodil

Ifenprodil Structure
Ifenprodil
  • CAS No.23210-56-2
  • Chemical Name:Ifenprodil
  • CBNumber:CB3427239
  • Molecular Formula:C21H27NO2
  • Formula Weight:325.45
  • MOL File:23210-56-2.mol
Ifenprodil Property
  • Melting point 114°
  • Boiling point 463.62°C (rough estimate)
  • Density 1.0825 (rough estimate)
  • refractive index 1.5614 (estimate)
  • storage temp. Store at RT
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 9.99±0.26(Predicted)
  • color White to Off-White
  • Water Solubility Soluble to 15 mM in water with gentle warming
  • FDA UNII R8OE3P6O5S
  • ATC code C04AX28
Safety
  • Toxicity :LD50 oral in mouse: 320mg/kg
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312a-P330-P501a
Ifenprodil Price More Price(2)
  • Brand: ALFA India
  • Product number: ALF-J60932-MF
  • Product name : Ifenprodil hemitartrate, 99%
  • Purity: 
  • Packaging: 50mg
  • Price: ₹33621
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-J60932-MA
  • Product name : Ifenprodil hemitartrate, 99%
  • Purity: 
  • Packaging: 10mg
  • Price: ₹18542
  • Updated: 2022/05/26
  • Buy: Buy

Ifenprodil Chemical Properties,Usage,Production

  • Originator Vadilex,Carriere,France,1972
  • Uses vasodilator
  • Uses Ifenprodil is a NMDA receptor antagonist.
  • Definition ChEBI: 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol is a member of piperidines.
  • Manufacturing Process The initial steps involve reacting benzyl chloride with 4- hydroxypropiophenone. The benzyloxypropiophene thus obtained is first brominated and then reacted with 4-benzylpiperidine to give 1-(pbenzyloxyphenyl)-2-(4-benzyl-piperidino)propan-1-one.
    The neutral tartrate may be prepared directly by reduction of 1-(pbenzyloxyphenyl)-2-(4-benzyl-piperidino)propan-1-one. For the reduction, a mixture of 175 g of ketone (0.425 mol) and 32 g of tartaric acid (0.213 mol) is hydrogenated at 50°C under pressure of 50 kg/cm2 in 440 ml of methanol in the presence of 12 g of palladium on charcoal.
    The catalyst is filtered off at elevated temperature, and the filtrate is concentrated by evaporation under reduced pressure to a volume of 300 ml and added in a thin stream to 2.5 liters of diethyl ether with mechanical agitation. The precipitate is separated, washed with diethyl ether and dried in vacuo at 80° to 85°C for several hours. 325 g (96% yield) of the neutral tartrate of 1-(p-hydroxyphenyl)-2-(4-benzyl-piperidino)propan-1-ol are obtained.
  • Therapeutic Function Vasodilator
  • Biological Activity NMDA receptor antagonist, acting at the polyamine site. Also an α -adrenergic vasodilator. σ 2 ligand displaying about 3-fold selectivity over σ 1 sites.
Ifenprodil Preparation Products And Raw materials
Raw materials
Preparation Products
Ifenprodil Suppliers
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Ifenprodil Spectrum
23210-56-2, IfenprodilRelated Search:
  • API
  • Glutamate receptor
  • 抑制剂
  • 贝尔卡主打
  • 医药原料
  • C21H27NO2189C4H6O6
  • C46H60N2O10
  • 艾芬地尔,10 MM DMSO 溶液
  • 酒石酸苄哌酚胺
  • 2-(4-苄基哌啶基)-1-(4-羟基苯基)丙醇
  • 艾芬地尔
  • 苄哌酚醇
  • 23210-56-2
  • Ifenprodil, 10 mM in DMSO
  • 1-Piperidineethanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-
  • 2-?(4-?Benzylpiperidino)?-?1-?(1-?hydroxyphenyl)?-?1-?propanol
  • (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
  • 4-[(1S,2R)-1-hydroxy-2-[4-(phenylmethyl)-1-piperidin-1-iumyl]propyl]phenol
  • 4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
  • (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanolhemitartrate
  • 1-Piperidineethanol, .alpha.-(4-hydroxyphenyl)-.beta.-methyl-4-(phenylmethyl)-
  • 4-[2-[4-(benzyl)-1-piperidyl]-1-hydroxy-propyl]phenol
  • 4-[1-Hydroxy-2-[4-(phenylmethyl)piperidin-1-yl]propyl]phenol
  • 2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol
  • alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidineethanol
  • 2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol
  • 1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine)
  • α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol
  • 4-Benzyl-α-(p-hydroxyphenyl)-β-methyl-1-piperidineethanol
  • 2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propan-1-ol
  • 1-(4-Hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol
  • 2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol tartrate (2:1) salt
  • IFENPRODIL
  • alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidineethano
  • 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol
  • 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethano

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