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NUARIMOL

CAS No.63284-71-9
Chemical Name:NUARIMOL
CBNumber:CB3375554
Molecular Formula:C17H12ClFN2O
Formula Weight:314.74
MOL File:63284-71-9.mol

NUARIMOL Property

Melting point 126°C
Boiling point 475.2±40.0 °C(Predicted)
Density 1.3255 (estimate)
vapor pressure 1 x 10^-5 Pa at 23 °C
storage temp. 0-6°C
solubility Chloroform (Slightly), Methanol (Slightly)
Water Solubility 26 mg l^-1 (pH 7) at 25 °C
pka 11.37±0.29(Predicted)
color White to Pale Yellow
BRN 6223667
FDA UNII ZU7K80U0CY
EPA Substance Registry System Nuarimol (63284-71-9)
Pesticides Freedom of Information Act (FOIA) Nuarimol
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn
Risk Statements :22-36
Safety Statements :26
WGK Germany :3
RTECS :UV9279700

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H319
Precautionary statements P264-P270-P280-P301+P312-P305+P351+P338-P337+P313

NUARIMOL Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: 31116
Product name : Nuarimol
Purity: PESTANAL?, analytical standard
Packaging: 100MG
Price: ₹4156.8
Updated: 2022/06/14
Buy: Buy

NUARIMOL Chemical Properties,Usage,Production

Uses Nuarimol is used in the preparation of difluoroethyl-containing heterocyclic compounds useful as antiviral agents and fungicides. Also used as a substance in the modelling inhibition of avian aromatase by azole pesticides.
Uses Nuarimol is a systemic fungicide with both curative and protective activity. It controls a wide range of pathogenic fungi, e.g. Cercosporella spp., Septoria spp., Ustilago spp., powdery mildews, leaf spot, etc. in cereals (as a foliar spray and as a seed treatment), powdery mildews on pome fruits, stone fruits, vines, cucurbits and other crops and scab on apples.
Metabolic pathway Photolytic degradation is the primary dissipation mechanism of nuarimol in the environment. Major degradation reactions observed on plants/soil surfaces and water include hydroxylation of the phenyl groups, oxidation of the carbinol carbon atom, dehalogenation and carbinol dehydroxylation (Scheme 1). The primary metabolic pathway of nuarimol in rats involves mainly aryl hydroxylation (Scheme 2).
Degradation Nuarimol is stable to hydrolytic degradation when maintained in sterile buffered solutions (pH 3,6 and 9) in the dark at 52 °C (Saunders, 1977). It was readily degraded in distilled water via photolysis. The photolytic DT₅₀ of nuarimol was approximately 1 hour. Numerous photoproducts were observed; however, no structural characterisation information was reported (Zornes and Donoho, 1978).
Nuarimol was extensively photodegraded on solid surfaces. More than 80 photodegradation products were observed when nuarimol was exposed to sunlight on a stainless steel surface for up to 150 hours (Althaus, 1980a). All photoproducts were formed at very low levels (less than 3% each). The structures of 23 photoproducts were identified. An abbreviated photodegradation pathway of nuarimol (based on products accounting for 1% or greater) is presented in Scheme 1. These products were generated from the following reactions: aryl hydroxylation of the chlorophenyl and fluorophenyl moieties (to yield 2, 3), cleavage of the pyrimidine ring and the oxidation of the carbinol carbon atom (4,5) and dehydroxylation of the carbinol moiety (6). Carboxylic acid fragments from the phenyl(7,8,9) and pyrimidine moieties (10), resulting from the cleavage of the parent phenyl and pyrimidine linkages, were also observed.