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DIACYLGLYCEROL KINASE INHIBITOR I

DIACYLGLYCEROL KINASE INHIBITOR I Structure
DIACYLGLYCEROL KINASE INHIBITOR I
  • CAS No.93076-89-2
  • Chemical Name:DIACYLGLYCEROL KINASE INHIBITOR I
  • CBNumber:CB3335279
  • Molecular Formula:C27H26FN3OS
  • Formula Weight:459.58
  • MOL File:93076-89-2.mol
DIACYLGLYCEROL KINASE INHIBITOR I Property
  • Boiling point 619.8±65.0 °C(Predicted)
  • Density 1.26±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility 0.1 M HCl: slightly soluble
  • form solid
  • pka 7.76±0.20(Predicted)
  • color pale yellow
  • biological source synthetic (organic)
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
  • FDA UNII PF550QIT3I
  • UNSPSC Code 51111800
  • NACRES NA.77
Safety
  • Safety Statements  :23-24/25
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
DIACYLGLYCEROL KINASE INHIBITOR I Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: D5919
  • Product name : Diacylglycerol Kinase Inhibitor I
  • Purity: solid
  • Packaging: 1MG
  • Price: ₹11247.18
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D5919
  • Product name : Diacylglycerol Kinase Inhibitor I
  • Purity: solid
  • Packaging: 5MG
  • Price: ₹36783.35
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 266785
  • Product name : Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem
  • Purity: The Diacylglycerol Kinase Inhibitor I, also referenced under CAS 93076-89-2, controls the biological activity of Diacylglycerol Kinase. This small mol
  • Packaging: 5MG
  • Price: ₹15469.99
  • Updated: 2022/06/14
  • Buy: Buy

DIACYLGLYCEROL KINASE INHIBITOR I Chemical Properties,Usage,Production

  • Description R-59022 (93076-89-2) is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 μM in intact platelets).1 Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism.2 Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.3 Blocks filovirus internalization in host cells.4
  • Uses R-59-022 acts as an inducer of apoptosis in glioblastoma cells and avoids apoptosis in non-cancerous cells. This selectivity makes this drug a highly effective anti-cancer agent. Diacylglycerol Kinase inhibitor.
  • Definition ChEBI: 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]-1-piperidinyl]ethyl]-7-methyl-5-thiazolo[3,2-a]pyrimidinone is a diarylmethane.
  • Biological Activity Diacylglycerol (DAG) kinase inhibitor (IC 50 = 2.8 μ M); increases protein kinase C activity. Potentiates thrombin-induced platelet aggregation and induces neutrophil chemotaxis. Inhibits U46619-induced contractions in mouse aorta and porcine coronary artery.
  • in vivo

    R 59-022 (2 mg/kg, i.p., 12 days) significantly increases median survival in SCID mice implanted with U87 GBM cells[6].

    Animal Model:SCID mice implanted with U87 GBM cells[6]
    Dosage:10 mg/kg
    Administration:Intraperitoneal injection (i.p.)
    Result:Increased median survival and decreased tumor volume.
  • IC 50 PKC; serotonin; diacylglycerol kinase: 2.8 μM (IC50)
  • References de Chaffoy de Courcelles et al. (1985), R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet; J. Biol. Chem., 260 15762 Takita et al. (2011), Diacylglycerol kinase inhibitor R59022-induced autophagy and apoptosis in the neuronal cell line NG108-15; Arch. Biochem. Biophys., 509 197 Martinez et al. (2013), Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes; J. Lipid Res., 54 662 Stewart et al. (2019), A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells; Viruses, 11 206
DIACYLGLYCEROL KINASE INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
DIACYLGLYCEROL KINASE INHIBITOR I Suppliers
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DIACYLGLYCEROL KINASE INHIBITOR I Spectrum
93076-89-2, DIACYLGLYCEROL KINASE INHIBITOR IRelated Search:
  • Lipid signaling
  • 酶
  • 抑制剂
  • BioChemical
  • Biochemicals and Reagents
  • Application Index
  • Cell Signaling Enzymes
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • Signal Transduction
  • Enzymes, Inhibitors, and Substrates
  • Diacylglycerol kinase (DAGK)
  • IRDYE 800CW标记的二酰基甘油激酶5/DGK-Ε抗体
  • AP标记的二酰基甘油激酶5/DGK-Ε抗体
  • HRP标记的二酰基甘油激酶5/DGK-Ε抗体
  • BIOTIN标记的二酰基甘油激酶5/DGK-Ε抗体
  • R 59-022 |CAS 93076-89-2
  • 甘油二酯激酶
  • 二乙酰基甘油激酶
  • 6-(2-(4-((4-氟苯基)(苯基)亚甲基)哌啶-1-基)乙基)-7-甲基-5H-噻唑并[3,2-A]嘧啶-5-酮
  • 化合物 R 59-022
  • 二酰基甘油激酶抑制剂
  • R 59-022,二酰基甘油激酶抑制剂
  • 化合物 T16709
  • 二酰基甘油激酶5/DGK-Ε抗体
  • 93076-89-2
  • R 59022,R 59 022
  • DKGI-I
  • Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem
  • 6-[2-[4-[(4-fluorophenyl)-phenylmethylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
  • 6-[2-[4-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
  • 6-[2-[(4-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL)ETHYL]-7-METHYL-5H-THIAZOLO-[3,2-A]-PYRIMIDIN-5-ONE
  • 6-[2-[4-[(P-FLUOROPHENYL)PHENYLMETHYLENE]-1-PIPERIDINYL]ETHYL]-7-METHYL-5H-THIAZOLO(3,2-A)PYRIMIDINE-5-ONE
  • Anti-DGKD, N-Terminal antibody produced in rabbit
  • Diglyceride kinase κ
  • DGKI
  • Anti-DGKI, C-Terminal antibody produced in rabbit
  • DGK-θ
  • DAGK7
  • DAGK4
  • Anti-DGKQ, C-Terminal antibody produced in rabbit
  • DGKE
  • 6-[2-[4-[(4-Fluorophenyl)phenylMethylene]-1-piperidin-yl]ethyl]-7-Methyl-5H-thiazolo-[3,2-a]-pyriMidin-5-one, R59022
  • 6-(2-(4-((4-Fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo(3,2-A)pyrimidine-5-one
  • 5H-Thiazolo(3,2-A)pyrimidin-5-one, 6-(2-(4-((4-fluorophenyl)phenylmethylene)-1-piperidinyl)ethyl)-7-methyl-
  • sn-1,2-Diacylglycerol kinase, DAGK
  • Diacylglycerol Kinase from Escherichia coli
  • R59022, 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo-[3,2-a]-pyrimidin-5-one
  • DIACYLGLYCEROL KINASE SOLUTION
  • 6-[2-[4-[(4-fluorophenyl)phenylmethylene]-1-piperidin-yl]ethyl]-7-methyl-5h-thiazolo-[3,2-a]-pyrimidin-5-one
  • DIACYLGLYCEROL KINASE FROM E. COLI
  • R59022
  • SN-1,2-DIACYLGLYCEROL KINASE, RECOMBINANT, E COLI
  • SN-1,2-DIACYLGLYCEROL KINASE
  • DKI
  • EC: 2.7.1.107

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