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Doxycycline monohydrate

Doxycycline monohydrate Structure
Doxycycline monohydrate
  • CAS No.17086-28-1
  • Chemical Name:Doxycycline monohydrate
  • CBNumber:CB3289107
  • Molecular Formula:C22H26N2O9
  • Formula Weight:462.45
  • MOL File:17086-28-1.mol
Doxycycline monohydrate Property
  • Melting point 167-168℃
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility DMSO: soluble1mg/mL
  • form powder or crystals
  • color Light Yellow
  • Water Solubility Soluble in ethanol or methanol. Sparingly soluble in water.Soluble in dilute acids, alkali hydroxides and dimethyl sulfoxide.
  • CAS DataBase Reference 17086-28-1
  • FDA UNII N12000U13O
  • Proposition 65 List Doxycycline Monohydrate (internal use)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312+P330-P501
Doxycycline monohydrate Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: D1822
  • Product name : Doxycycline monohydrate
  • Purity: 
  • Packaging: 500MG
  • Price: ₹7480.08
  • Updated: 2022/06/14
  • Buy: Buy

Doxycycline monohydrate Chemical Properties,Usage,Production

  • Description Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.
  • Chemical Properties Doxycycline monohydrate is a Yellow, crystalline powder. It is soluble in ethanol or methanol. It has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. It is very slightly soluble in water.
  • Uses An antimicrobial. Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinasesDoxycycline monohydrate acts as an antibiotic, antimicrobial agent and a matrix metalloproteinase inhibitor. It is also used for the treatment of chloroquine-resistant falciparum malaria. Further, it is used to treat a wide variety of bacterial infections, including those that cause acne. In addition to this, it inhibits the bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome.
  • Uses Doxycycline Monohydrate is used to treat bacterial infections, Lyme disease, chlamydia, Rocky Mountain Spotted Fever, and other susceptible bacterial infections. It is an antibiotic with bacteriostatic properties.
    Tetracycline antibacterial.
  • Application In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
    It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
    It has also been used as an antimicrobial agent.
  • Indications Doxycycline monohydrate (Vibramycin Monohydrate, Monodox, Mondoxyne NL) is a moderately priced drug used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Generic doxycycline monohydrate is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of doxycycline monohydrate is around $6.02, 80% off the average retail price of $30.66. Compare tetracycline antibiotics.
  • Definition ChEBI: The monohydrate form of doxycycline. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary isease (COPD), and adult periodontitis.
  • brand name Doxychel (Rachelle); Monodox (Oclassen); Oracea (CollaGenex); Vibramycin (Pfizer).
  • General Description Doxycycline was synthesized by Pfizer starting with either tetracycline or oxytetracycline in 1958. It shows about fourfold higher antibacterial activity than tetracycline against a variety of pathogens. Doxycycline shows higher oral absorption than tetracycline, and its concentration in tissue is higher and maintained longer. Hyclate is a preparation of doxycycline containing one mole of hydrochloric acid and one-half mole each of ethanol and water per mole of doxycycline.
  • Biological Activity Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.
Doxycycline monohydrate Preparation Products And Raw materials
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Doxycycline monohydrate Spectrum
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  • C22H24N2O8xH2O
  • 17080-28-1
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