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Arterolane

Arterolane Structure
Arterolane
  • CAS No.664338-39-0
  • Chemical Name:Arterolane
  • CBNumber:CB32563434
  • Molecular Formula:C22H36N2O4
  • Formula Weight:392.53
  • MOL File:664338-39-0.mol
Arterolane Property
  • Melting point 160-162℃
  • Boiling point 572.2±45.0 °C(Predicted)
  • Density 1.20
  • storage temp. Store at -20°C, protect from light, stored under nitrogen
  • solubility DMSO: soluble
  • form A solid
  • pka 16.70±0.46(Predicted)
  • color White to off-white
  • FDA UNII 3N1TN351VB
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Arterolane Chemical Properties,Usage,Production

  • Uses Arterolane is an antimalarial agent, with IC50 of both 1.1 nM against P. falciparum Ro73 and W2, respectively.
  • Definition ChEBI: Arterolane is an oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine. It has a role as an antimalarial and an antiplasmodial drug. It is a member of adamantanes, a secondary carboxamide, a primary amino compound, a trioxolane and an oxaspiro compound. It is a conjugate base of an arterolane(1+).
  • References [1] Vennerstrom JL, et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature. 2004 Aug 19;430(7002):900-4. DOI:10.1038/nature02779
Arterolane Preparation Products And Raw materials
Raw materials
Preparation Products
Arterolane Suppliers
Global(35)Suppliers
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  • Supplier：
    TargetMol Chemicals Inc.
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    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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Arterolane Spectrum
664338-39-0, ArterolaneRelated Search:
  • 抑制剂
  • 化合物 T14325
  • 青蒿氧烷
  • 664338-39-0
  • Arterolane MaleateQ: What is Arterolane Maleate Q: What is the CAS Number of Arterolane Maleate Q: What is the storage condition of Arterolane Maleate
  • -tricyclo[3.3.1.13,7]decane]-4-acetamide
  • cis-N-(2-Amino-2-methylpropyl)dispiro[cyclohexane-1,3&rsquo
  • -[1,2,4]trioxolane-5&rsquo
  • Dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.13,7]decane]-4-acetamide, N-(2-amino-2-methylpropyl)-, cis-
  • RBx 11160)
  • Arterolane (OZ277
  • OZ 277
  • Arterolane

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