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(-)-MDL 100907

(-)-MDL 100907 Structure
(-)-MDL 100907
  • CAS No.175673-57-1
  • Chemical Name:(-)-MDL 100907
  • CBNumber:CB32454075
  • Molecular Formula:C22H28FNO3
  • Formula Weight:373.465
  • MOL File:175673-57-1.mol
(-)-MDL 100907 Property
  • Boiling point 499.4±45.0 °C(Predicted)
  • Density 1.150±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • pka 13.93±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

(-)-MDL 100907 Chemical Properties,Usage,Production

  • Uses (S)-Volinanserin is an isform of Volinanserin (HY-14940). Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.
  • in vivo

    Volinanserin (MDL 100907; 0.008-2.0 mg/kg, i.p.) significantly decreases d-amphetamine-stimulated locomotor activity in mice, with an ED50 of 0.3 mg/kg, but shows no obvious reduction in the base-line locomotor activity in mice. Volinanserin produces atalepsy with an ED50 of 10-50 mg/kg in rats. Volinanserin does not reduces apomorphine-induced stereotypies or produces catalepsy in rats[1]. Volinanserin (M100907) combined with MK-801 significantly decreases reinforcers at 1 μg/kg, but dose-dependently (10, 100 μg/kg) antagonizes the disruptive effect of MK-801 in rats via i.p. administration. Volinanserin (6.25 μg/kg) enhances the antidepressant-like action of Desipramine (HY-B1272A) in rats performing under a DRL 72-s schedule, and elevates the antidepressant-like effect of Tranylcypromine (HY-17447)[2].

  • References [1] Sorensen SM, et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacol Exp Ther. 1993 Aug;266(2):684-91. PMID:8102646
    [2] Ardayfio PA, et al. The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. J Pharmacol Exp Ther. 2008 Dec;327(3):891-7. DOI:10.1124/jpet.108.143370
(-)-MDL 100907 Preparation Products And Raw materials
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(-)-MDL 100907 Spectrum
175673-57-1, (-)-MDL 100907Related Search:
  • Selective 5-HT2A antagonist.
  • 化学试剂
  • 抑制剂
  • 化合物MDL 100009,10 MM DMSO 溶液
  • (S)-(2,3-二甲氧基苯基)(1-(4-氟苯乙基)哌啶-4-基)甲醇
  • (-)-MDL 100907
  • 化合物MDL 100009
  • 175673-57-1
  • (?)-Volinanserin
  • MDL 100009, 10 mM in DMSO
  • MDL 100009(MDL100009)
  • (S)-(2,3-Dimethoxyphenyl)(1-(4-fluorophenethyl)piperidin-4-yl)methanol
  • 4-Piperidinemethanol, α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-, (αS)-
  • MDL 100009 - MDL 100907, (S)-(-)-
  • MDL 100009
  • M 100009
  • 4-PIPERIDINEMETHANOL, A-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-, (AS)-
  • (S)-MDL 100907
  • (S)-(2,3-DIMETHOXY-PHENYL)-(1-[2-(4-FLUORO-PHENYL)-ETHYL]-PIPERIDIN-4-YL)-METHANOL

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