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FRAKEFAMIDE

FRAKEFAMIDE Structure
FRAKEFAMIDE
  • CAS No.188196-22-7
  • Chemical Name:FRAKEFAMIDE
  • CBNumber:CB32451403
  • Molecular Formula:C30H34FN5O5
  • Formula Weight:563.62
  • MOL File:188196-22-7.mol
FRAKEFAMIDE Property
  • Boiling point 973.0±65.0 °C(Predicted)
  • Density 1.295±0.06 g/cm3(Predicted)
  • pka 9.97±0.15(Predicted)
  • FDA UNII DM32B4GU70
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

FRAKEFAMIDE Chemical Properties,Usage,Production

  • Uses Frakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2].
  • in vivo

    Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2].

  • References [1] Modalen AO, et al. A novel molecule (frakefamide) with peripheral opioid properties: the effects on resting ventilation compared with morphine and placebo. Anesth Analg. 2005 Mar;100(3):713-7. DOI:10.1213/01.ANE.0000145011.75545.C5
    [2] Swedberg MD, et al. Drug discrimination: A versatile tool for characterization of CNS safety pharmacology and potential for drug abuse. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:295-305. DOI:10.1016/j.vascn.2016.05.011
FRAKEFAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
FRAKEFAMIDE Suppliers
Global(9)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：marketing@targetmol.com
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：support@targetmol.com
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Email：zijue.cai@tsbiochem.com
  • Country：United States
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  • Supplier： TargetMol Chemicals Inc.
  • Tel： 15002134094
  • Email：marketing@targetmol.cn
  • Country：China
  • ProdList：19746
  • Advantage：58
FRAKEFAMIDE Spectrum
188196-22-7, FRAKEFAMIDERelated Search:
  • 抑制剂
  • 化合物 FRAKEFAMIDE
  • 化合物 T11323L
  • 188196-22-7
  • L-Phenylalaninamide, L-tyrosyl-D-alanyl-4-fluoro-L-phenylalanyl-
  • L-Tyrosyl-D-alanyl-L-(4-fluoro)phenylalanyl-L-phenylalanylamide
  • FRAKEFAMIDE

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