ChemicalBook > CAS DataBase List > Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Structure
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester
  • CAS No.159749-28-7
  • Chemical Name:Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester
  • CBNumber:CB3215522
  • Molecular Formula:C9H15NO4
  • Formula Weight:201.22
  • MOL File:159749-28-7.mol
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Property
  • Boiling point 321.0±35.0 °C(Predicted)
  • Density 1.246±0.06 g/cm3(Predicted)
  • storage temp. 2-8°C
  • pka 4.01±0.20(Predicted)
  • form solid
  • color Pale yellow
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Chemical Properties,Usage,Production

  • Description Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester (ADCBT) is a pyrrolidinyl nicotinic acetylcholine receptor agonist. ADCBT has been shown to have affinity values for neuronal nicotinic acetylcholine receptors that are significantly higher than those of nicotine. It has been shown to be regioselective in the sense that it binds preferentially to the alpha4beta2 subtype of the nicotinic acetylcholine receptor, which is present in both peripheral and central neurons. It also has a high affinity for the acetylcholine binding site at the neuromuscular junction. ADCBT has been shown to have analgesic effects in animal studies.
  • Chemical Properties White powder
  • Uses Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester, is an useful intermediate in the synthesis of pharmaceutical compounds including inhibitors and receptor Antagonists. It can be used in the synthesis of polypeptides.
  • Preparation Sodium hydroxide (2.08 g, 51.92 mmol) was added to a solution of azetidine-2-carboxylic acid (5.00 g, 49.50 mmol), di-tert-butyl dicarbonate (13.50 g, 61.80 mmol) in ethanol (120.0 mL) at 0 °C. After stirring the reaction mixture for 8 hours, the pH of the mixture was adjusted to 2 with 1.0 N HCl and extracted with ethyl acetate (2 × 200 mL). The combined organic layers were washed with brine, separated, and dried over anhydrous sodium sulfate. Then the compound was concentrated under reduced pressure to afford Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester.
    AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Suppliers
Global(148)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Accela ChemBio Inc.
  • Tel：+1-858-6993322
  • Email：info@accelachem.com
  • Country：United States
  • ProdList：19825
  • Advantage：58
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Spectrum
159749-28-7, Azetidine-1,2-dicarboxylic acid 1-tert-butyl esterRelated Search:
  • pharmacetical
  • 通用试剂
  • 高端化学
  • 药物中间体
  • 氨基酸
  • 医药中间体
  • 1-[(叔-丁氧基)羰基]吖丁啶-2-羧酸
  • 1-BOC-2-氮杂环丁烷甲酸
  • 1-BOC-氮杂环丁烷-2-羧酸
  • N-BOC-2-氮杂环丁基甲酸
  • N-BOC-RS-2-氮杂环丁烷-1-羧酸
  • 1-叔丁氧羰基-氮杂环丁烷-2-甲酸
  • 1-BOC-2-甲酸氮杂环丁烷
  • 1-叔丁氧羰基-L-氮杂环丁烷-2-甲酸
  • N-BOC-氮杂环丁烷-2-羧酸
  • N-BOC-氮杂环丁烷-2-甲酸
  • AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER N-BOC-氮杂环丁烷-2-羧酸
  • 1-BOC-吖啶-2-羧酸
  • 1-BOC-氮杂环丁烷-2-甲酸
  • 159749-28-7
  • 1-Boc-azetidine-2-carboxylic acid
  • Azetidine-1,2-dicarboxylic acid ID 1-tert-butyl este
  • Boc-DL-Aze-OH
  • N-Boc-RS-2-Azetidinecarboxylic acid
  • Azetidine-1,2-dicarboxylic acid ID 1-tert-butyl ester
  • 1,2-Azetidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester
  • Azetidine-1,2-Carboxylic acid 1-tert-butyl ester
  • 1-[(2-Methylpropan-2-yl)oxycarbonyl]azetidine-2-carboxylic Acid
  • AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER N-BOC-
  • 1-Boc-L-azetidine-2-carboxylic acid
  • N-Boc-Azetidine-2-carboxylic acid
  • 1-N-BOC-AZETIDINE-2-CARBOXYLIC ACID
  • BOC-AZETIDINE-2-CARBOXYLIC ACID
  • AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

Home

My