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Ethopropazine Hydrochloride

Ethopropazine Hydrochloride Structure
Ethopropazine Hydrochloride
  • CAS No.1094-08-2
  • Chemical Name:Ethopropazine Hydrochloride
  • CBNumber:CB3149595
  • Molecular Formula:C19H25ClN2S
  • Formula Weight:348.93
  • MOL File:1094-08-2.mol
Ethopropazine Hydrochloride Property
  • Melting point 223-225° (some decompn)
  • storage temp. 2-8°C
  • solubility DMSO: >5mg/mL at ~60°C, clear
  • form powder
  • color white
  • Merck 13,3783
  • Stability Hygroscopic
  • FDA UNII O00T1I1VRN
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • WGK Germany  :3
  • RTECS  :SO5002000
  • Toxicity :LD50 s.c. in mice: 670 mg/kg (Farquharson, Johnston)
  • NFPA 704:
    0
    1 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P264-P270-P301+P312-P330-P501
Ethopropazine Hydrochloride Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: E5406
  • Product name : Ethopropazine hydrochloride
  • Purity: ≥98% (HPLC), powder
  • Packaging: 50MG
  • Price: ₹20448.43
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: E5406
  • Product name : Ethopropazine hydrochloride
  • Purity: ≥98% (HPLC), powder
  • Packaging: 250MG
  • Price: ₹82118.45
  • Updated: 2022/06/14
  • Buy: Buy

Ethopropazine Hydrochloride Chemical Properties,Usage,Production

  • Originator Parsidol,Warner Lambert,US,1954
  • Uses Antiparkinsonian;Anticholinergic
  • Uses Ethopropazine hydrochloride is a drug that shifts energy metabolism from mitochondrial respiration to glycolysis.
  • Definition ChEBI: The monohydrochloride salt of profenamine. An antimuscarinic, it is used for the symptomatic treatment of Parkinson's disease.
  • Manufacturing Process 6.2 grams of phenthiazine in 100 cc of warm dry benzene was added during 1 hour with stirring, and in an atmosphere of hydrogen, to the Grignard reagent prepared from 1 gram of magnesium, 6.2 grams of methyl iodide, and 20 cc of dry ether. After boiling for 30 minutes, a solution of 6.6 grams of 2-chloro- 1-diethylamino propane in 10 cc of dry benzene was added during 1 hour to the boiling solution, and heating was maintained for a further 1.5 hours.
    The reaction mixture was then cooled and treated with aqueous ammonium chloride and chloroform added to dissolve an oil at the interface of the benzene and aqueous layers. The chloroform-benzene extract was extracted with 2 N hydrochloric acid and the acid extract was basified at 5° to 10°C with 50% aqueous sodium hydroxide.
    There was obtained a mixture of N-(2'-diethylamino-2'- methylethyl)phenthiazine and N-(2'-diethylamino-1'-methylethyl)phenthiazine in the form of a viscous yellow oil, BP 202° to 205°C/2 mm. This oil was treated in ethereal solution with ethereal hydrogen chloride and gave a white solid which was fractionally crystallized from ethylene dichloride. The less soluble fraction, N-(2'-diethylamino-2'-methylethyl)phenthiazine hydrochloride formed colorless rhombs, MP 223° to 225°C. The more soluble N-(2'- diethylamino-1'-methylethyl)phenthiazine hydrochloride was obtained as colorless prismatic needles, MP 166° to 168°C.
  • Therapeutic Function Antiparkinsonian
  • General Description Ethopropazinehydrochloride, 10-[2-(diethylamino)propyl]phenothiazinemonohydrochloride (Parsidol), introduced to therapy in1954, has antimuscarinic activity and is especially useful inthe symptomatic treatment of parkinsonism. In this capacity,it has value in controlling rigidity, and it also has a favorableeffect on tremor, sialorrhea, and oculogyric crises.
  • Biochem/physiol Actions Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.
  • Clinical Use Ethopropazine Hydrochloride is oftenused in conjunction with other antiparkinsonian drugs forcomplementary activity.Side effects are common with this drug but are usuallynot severe. Drowsiness and dizziness are the most commonside effects at ordinary dosage levels, and as the dose increases,xerostomia, mydriasis, and others become evident.It is contraindicated in conditions such as glaucoma becauseof its mydriatic effect.
Ethopropazine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ethopropazine Hydrochloride Suppliers
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Ethopropazine Hydrochloride Spectrum
1094-08-2, Ethopropazine HydrochlorideRelated Search:
  • 抑制剂
  • 配体家族
  • 有机中间体
  • 中间体
  • C19H25ClN2S
  • C19H24N2SHCl
  • 化合物 ETHOPROPAZINE HYDROCHLORIDE
  • N,N-二乙基-1-(10H-吩噻嗪-10-基)丙-2-胺盐酸盐
  • 化合物 T21393
  • 盐酸乙丙嗪
  • 爱普把嗪
  • 盐酸二乙基异丙嗪
  • 盐酸普罗芬胺
  • 二乙异丙嗪 盐酸盐
  • 10-(2-二乙氨基丙基)吩噻嗪
  • 1094-08-2
  • Ethopropazine hydrochloride >=98% (HPLC), powder
  • PROFENAMIN HCL
  • Ethopropazine hydroc
  • Profenamine HCl
  • l-10-(2-diethylaminopropyl)phenothiazinehydrochloride
  • isothazinehydrochloride
  • 10-(2-(diethylamino)propyl)-phenothiazinmonohydrochloride
  • SALOR-INT L308765-1EA
  • ETHOPROPAZINE HYDROCHLORIDE
  • LABOTEST-BB LT00452011
  • 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE
  • profenaminehydrochloride
  • parsidolmonohydrochloride
  • parsidolhydrochloride
  • parfezin
  • N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride
  • N-(2-diethylaMinopropyl)-phenothiazine hydrochloride
  • 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride
  • ProphenamineHCl
  • N,N-diethyl-alpha-methyl-10H-phenothiazine-10-ethylamine monohydrochloride
  • 10-(2-Diethylaminopropyl)phenothiazine, 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride, Dibutil hydrochloride, Parkin
  • Phenothiazine, 10-[2-(diethylamino)propyl]-, monohydrochloride (8CI)
  • Phenothiazine, 10-[2-(diethylamino)propyl]-, hydrochloride (7CI)
  • NSC 64074
  • NSC 169467
  • 10H-Phenothiazine-10-ethanamine, N,N-diethyl-a-methyl-, monohydrochloride (9CI)
  • 10H-Phenothiazine-10-ethanamine, N,N-diethyl-.alpha.-methyl-, monohydrochloride
  • ethopropazine hcl
  • profenaminemonohydrochloride
  • n,n-diethyl-alpha-methyl-10-phenothiazineethylaminhydrochloride
  • n,n-diethyl-alpha-methyl-10h-phenothiazine-10-ethanaminmonohydrochloride
  • lysivanehydrochloride

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