ChemicalBook > CAS DataBase List > [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol

[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Structure
[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
  • CAS No.85081-18-1
  • Chemical Name:[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
  • CBNumber:CB31465696
  • Molecular Formula:C19H29NO3
  • Formula Weight:319.44
  • MOL File:85081-18-1.mol
[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Property
  • Melting point 106-108 °C(Solv: hexane (110-54-3))
  • Boiling point 457.8±45.0 °C(Predicted)
  • Density 1.13
  • storage temp. Store at -20°C
  • solubility DMSO : 33.33 mg/mL (104.34 mM; Need ultrasonic)
  • form Powder
  • pka 14.75±0.40(Predicted)
  • color White to off-white
  • FDA UNII IFRYDMLSGE
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H336-H301-H373
  • Precautionary statements P261-P271-P304+P340-P312-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P260-P314-P501

[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Chemical Properties,Usage,Production

  • Uses (+)-α-Dihydrotetrabenazine is a potent inhibitor of vascular monoamine transporter 2 (VMAT2) and an agent of significant interest for therapeutic and molecular imaging applications.
  • Definition ChEBI: (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol is a member of isoquinolines.
  • in vivo

    NBI-98782 (10 mg/kg, p.o., daily for 7 days) decreases basal and APDs-induced monoamine efflux in both mPFC and dSTR in male C57BL/6J mice[1].

    Animal Model:Male C57BL/6J mice[1]
    Dosage:10 mg/kg
    Administration:p.o., daily for 7 days
    Result:Decreased the efflux of DA, 5-HT and NE in mPFC, dSTR, HIP and NAC.
    Increased the efflux of DOPAC, HVA, and 5-HIAA in mPFC, dSTR, HIP and NAC.
    Decreased in cortical DA and DOPAC as well as striatal DA, 5-HT and NE efflux combinated with haloperidol (HY-14538, 0.5 mg/kg, i.p.).
    Decreased cortical Glu and striatal ACh, DA and GABA efflux combinated with Clozapine (HY-14539, 10 mg/kg, i.p.).
    Reduced PCP-induced increase in LMA between various time points.
    Suppressed clozapine-, olanzapine- and risperidone-induced DA efflux in both mPFC and dSTR, and ACh efflux in mPFC.
[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Suppliers
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[2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol Spectrum
85081-18-1, [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-olRelated Search:
  • Tetrabenazine
  • Impurities & Metabolites
  • 原料
  • 抑制剂
  • 杂质和代谢物
  • 医药中间体
  • (+)-Α-二氢丁苯那嗪,10 MM DMSO 溶液
  • 丁苯那嗪杂质27
  • (2R,3R,11BR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11B-六氢-1H-吡啶并[2,1-A]异喹啉-2-酚
  • 化合物NBI-98782
  • (+)-Α-二氢丁苯那嗪
  • (+)-Α-二氢川芎嗪
  • (2R,3R,11BR)-3-异丁基-9,10-二甲氧基-2,3,4,6,7,11B-六氢-1H-吡啶并[2,1-A]异喹啉-2-醇
  • [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-六氢-9,10-二甲氧基-3-异丁基-2H-苯并[a]喹嗪-2-醇
  • 85081-18-1
  • NBI-98782, 10 mM in DMSO
  • (2R,3R,11bR)-9,10-dimethoxy-3-(propan-2-yl)-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
  • (+)-Dihydrotetrabenazine
  • (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol
  • NBI 98782,NBI-98782,NBI98782,Monoamine Transporter,Inhibitor,inhibit
  • (+)-DTBZ
  • (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
  • (+)-α-Dihydrotetrabenazine
  • (+)-α-DHTBZ
  • Tetrabenazine Related Impurity 27
  • Tetrabenazine Related Impurity 27 (2R, 3R, 11bR)
  • (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol
  • (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
  • NBI-98782
  • [2R-(2a,3b,11bb)]-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol
  • 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
  • Tetrabenazine metabolite B
  • Tetrabenazine metabolite A

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