Uses
Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis[1].
Definition
ChEBI: Ramentaceone is a hydroxy-1,4-naphthoquinone.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 3766, 1984
DOI: 10.1021/jo00194a017
References
[1] Anna Kawiak, et al. Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells. PLoS One. 2016 Feb 3;11(2):e0147718. DOI:
10.1371/journal.pone.0147718
