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ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT

ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Structure
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
  • CAS No.71997-40-5
  • Chemical Name:ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT
  • CBNumber:CB3141054
  • Molecular Formula:C10H13N5NaO13P3
  • Formula Weight:527.15
  • MOL File:71997-40-5.mol
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Property
  • storage temp. -20°C
  • form White powder
  • color White to off-white
  • biological source bacterial (corynebacterium sp)
  • Water Solubility water: 50mg/mL
  • UNSPSC Code 41106305
  • NACRES NA.77
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: A6779
  • Product name : Adenosine 5′-triphosphate, periodate oxidized sodium salt
  • Purity: ≥97%
  • Packaging: 25MG
  • Price: ₹22613.43
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: A6779
  • Product name : Adenosine 5′-triphosphate, periodate oxidized sodium salt
  • Purity: ≥97%
  • Packaging: 100MG
  • Price: ₹63185.53
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 5.05758
  • Product name : Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem
  • Purity: 
  • Packaging: 25MG
  • Price: ₹21209.99
  • Updated: 2022/06/14
  • Buy: Buy

ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Chemical Properties,Usage,Production

  • Uses Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
    • as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
    • as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
    • to evaluate the physiological significance of elevated intracellular ATP levels
    • increased?P2rx7?expression for osteoclastogenesis in?Flcn-deficient cells

  • General Description A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (?100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts.
  • Biochem/physiol Actions Reversible: no
  • in vivo

    Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2].

    Animal Model:Induced mouse experimental autoimmune uveitis (EAU)[2]
    Dosage:300 μg/mouse
    Administration:i.p.
    Result:Showed almost undetected EAU, as shown by fundoscopic and pathologic examination.
    Decreased serum IL-17 level.
    Mitigated the autoreactive T cell response.
  • IC 50 NLRP3 inflammasome; P2X7 Receptor
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Suppliers
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ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Spectrum
71997-40-5, ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALTRelated Search:
  • 抑制剂
  • BioChemical
  • Biochemicals and Reagents
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleotides
  • C10H13N5NaO13P3
  • C10H14N5O13P3
  • 化合物 OXIDIZED ATP TRISODIUM SALT
  • 高碘酸氧化腺苷 5′-三磷酸 钠盐
  • 腺苷-5`-三磷酸钠盐,高碘酸氧化过的
  • 71997-40-5
  • Oxidized ATP (oATP)
  • ADENOSINE 5'-TRIPHOSPHATE PERIODATE OXIDIZED
  • Oxidized ATP trisodium salt
  • Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem
  • Adenosine 5′-triphosphate, periodate oxidized
  • Adenosine 5`-triphosphate sodiuM salt periodate oxidized
  • adenosine 5'-triphosphate-2',3'-dialdehyde
  • ADENOSINE 5-TRIPHOSPHATE, PERIODATEOXIDI ZED SODIUM
  • oATP
  • ADENOSINE 5'-TRIPHOSPHATE-2', 3'-DIALDEHYDE SODIUM SALT
  • ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT

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