Uses
Dibenamine is an alpha-adrenergic antagonist that exhibits the ability to block both basal and histamine-stimulated gastric acid secretion, making it therapeutically relevant in conditions involving excessive gastric acid production.
Safety Profile
Poison by intravenous
and intraperitoneal routes. Moderately toxic
by ingestion and subcutaneous routes.
Experimental reproductive effects. Can
cause leukopenia (reduced whte blood cell
count). Mutation data reported. When
heated to decomposition it emits very toxic
fumes of Cl and NOx. See also
AROMATIC MINES.
References
[1] The affinity and selectivity of α-adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D-adrenoceptors DOI:
10.1002/prp2.602
