ChemicalBook > CAS DataBase List > (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID

(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID

(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Structure
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
  • CAS No.121083-05-4
  • Chemical Name:(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
  • CBNumber:CB3118579
  • Molecular Formula:C22H21F2NO4S
  • Formula Weight:433.47
  • MOL File:121083-05-4.mol
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Property
  • Boiling point 693.4±55.0 °C(Predicted)
  • Density 1.43±0.1 g/cm3(Predicted)
  • storage temp. Store at RT
  • solubility Soluble to 100 mM in 1.1eq. NaOH
  • form Powder
  • pka 4.56±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
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(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Chemical Properties,Usage,Production

  • Uses L-670,596 is a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
  • Definition ChEBI: 2-[6,8-difluoro-9-[(4-methylsulfonylphenyl)methyl]-1,2,3,4-tetrahydrocarbazol-1-yl]acetic acid is a member of carbazoles.
  • Biological Activity Potent and selective thromboxane A 2 /prostaglandin endoperoxide receptor antagonist (IC 50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA 2 = 9.0) and human platelet aggregation in vitro (IC 50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo .
  • in vivo

    L-670596 (0.03mg/kg ; i.v.; single) inhibits arachidonic acid and U-44069 induced bronchoconstriction in the guinea pig[1].
    L-670596 (2 mg/kg; i.v.; single) inhibits platelet aggregation to collagen in pigs[2].

    Animal Model:Guinea pig (arachidonic acid and U-44069 induced bronchoconstriction model)[1].
    Dosage:0.03mg/kg
    Administration:Intravenous injection; single.
    Result:Inhibited arachidonic acid and U-44069 induced bronchoconstriction.
(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Preparation Products And Raw materials
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(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Suppliers
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(-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID Spectrum
121083-05-4, (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACIDRelated Search:
  • Prostanoid receptor and related
  • 抑制剂
  • C22H21F2NO4S
  • 化合物 L-670,596
  • 化合物 T22897
  • 121083-05-4
  • L670,596,L 670,596
  • 2-(6,8-Difluoro-9-(4-(methylsulfonyl)benzyl)-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid
  • (-)-6-8-DIFLUORO-2,3,4,9-TETRAHYDRO-9-[[4-(METHYLSULFONYL)PHENYL]METHYL]-1H-CARBAZOLE-1-ACETIC ACID
  • L-670,596

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