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CARDAMONIN

CAS No.19309-14-9
Chemical Name:CARDAMONIN
CBNumber:CB31092214
Molecular Formula:C16H14O4
Formula Weight:270.28
MOL File:19309-14-9.mol

CARDAMONIN Property

Melting point 199～200℃
Boiling point 484.5±45.0 °C(Predicted)
Density 1.282±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: ≥20mg/mL
form powder
pka 7.00±0.40(Predicted)
color yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.
FDA UNII H8KP1OJ8JX
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :N
Risk Statements :50/53
Safety Statements :61-24/25
RIDADR :UN 3077 9 / PGIII
HS Code :29242990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P264-P270-P301+P312-P501

CARDAMONIN Price More Price(3)

Brand: Sigma-Aldrich(India)
Product number: C8249
Product name : Cardamonin
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: ₹17060.2
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: C8249
Product name : Cardamonin
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: ₹68901.13
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 681672
Product name : Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem
Purity: The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/
Packaging: 2MG
Price: ₹17660.01
Updated: 2022/06/14
Buy: Buy

CARDAMONIN Chemical Properties,Usage,Production

Description Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3?Cell permeable.
Uses Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
Definition ChEBI: Cardamonin is a member of chalcones.
General Description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE 2 production from LPS- and IFN- γ -induced RAW cells and inhibits TXB 2 production via the COX-1 and COX-2 pathways. Inhibits NF- κ B activation via inhibition of I κ B α degradation and phosphorylation, I κ B kinase activation and NF- κ B nuclear translocation.
Biochem/physiol Actions Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.
storage Store at +4°C
References 1) Lee?et al. (2006),?Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamonin, a chalcone analog from Alpinia conchigera; J. Pharmacol. Exp. Ther.,?316?271 2) Israf?et al. (2007),?Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-kappaB nuclear translocation and Ikappa-B phosphorylation in RAW 264.7 macrophage cells; Mol. Immunol.,?44?673 3) Ahmad?et al. (2006),?Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood; Eur. Pharmacol. Exp. Ther., 538?188