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1,4-Bis(N,N'-diethylene phosphamide)piperazine

1,4-Bis(N,N'-diethylene phosphamide)piperazine Structure
1,4-Bis(N,N'-diethylene phosphamide)piperazine
  • CAS No.738-99-8
  • Chemical Name:1,4-Bis(N,N'-diethylene phosphamide)piperazine
  • CBNumber:CB31016667
  • Molecular Formula:C12H24N6O2P2
  • Formula Weight:346.31
  • MOL File:738-99-8.mol
1,4-Bis(N,N'-diethylene phosphamide)piperazine Property
  • Melting point 187°
  • form solid
  • color Crystals from C6H6
  • FDA UNII L16KNK08VM
Safety
  • Toxicity :LD50 orl-mus: 68 mg/kg RPTOAN 36,240,73
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

1,4-Bis(N,N'-diethylene phosphamide)piperazine Chemical Properties,Usage,Production

  • Uses Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research[1][2].
  • Safety Profile Poison by ingestion,intraperitoneal, and subcutaneous routes. Humanmutation data reported. When heated to decomposition itemits very toxic fumes of POx and NOx.
  • References [1] Factor VM, Radaeva SA, Thorgeirsson SS. Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol. 1994 Aug;145(2):409-22. PMID:8053498
    [2] Jensen MR, et al. Regulation of cyclin G1 during murine hepatic regeneration following Dipin-induced DNA damage. Hepatology. 1998 Aug;28(2):537-46. DOI:10.1002/hep.510280235
1,4-Bis(N,N'-diethylene phosphamide)piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
1,4-Bis(N,N'-diethylene phosphamide)piperazine Suppliers
Global(5)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
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  • Supplier：
    TargetMol Chemicals Inc.
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  • Country：United States
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  • Supplier： TargetMol Chemicals Inc.
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1,4-Bis(N,N'-diethylene phosphamide)piperazine Spectrum
738-99-8, 1,4-Bis(N,N'-diethylene phosphamide)piperazineRelated Search:
  • 抑制剂
  • 化学物质-药物相关的化学物质
  • C12H24N6O2P2
  • 化合物 DIPIN
  • 化合物 T25338
  • 738-99-8
  • NSC-80096
  • NSC80096
  • NSC 80096
  • Piperazine, 1,4-bis[bis(1-aziridinyl)phosphinyl]-
  • Dipine
  • 1,4-Piperazinediylbis[bis(1-aziridinyl)phosphine oxide]
  • PHOSPHINEOXIDE,1,4-PIPERAZINEDIYLBIS(BIS(1-AZIRIDINYL)-
  • 1,4-PIPERAZINEDIHYLBIS(BIS(1-AZIRIDINYL)-PHOPHINEOXIDE
  • dipin
  • 1,4-Bis(N,N'-diethylene phosphamide)piperazine

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