ChemicalBook > CAS DataBase List > Nosiheptide

Nosiheptide

Nosiheptide Structure
Nosiheptide
  • CAS No.56377-79-8
  • Chemical Name:Nosiheptide
  • CBNumber:CB2875431
  • Molecular Formula:C51H43N13O12S6
  • Formula Weight:1222.34
  • MOL File:56377-79-8.mol
Nosiheptide Property
  • Melting point 310-320° (dec)
  • alpha D20 +38° (c = 1 in pyridine)
  • Density 1.534±0.06 g/cm3(Predicted)
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility DMSO (Slightly), Methanol (Slightly)
  • form Solid
  • pka 1.42±0.60(Predicted)
  • color Light Yellow to Light Brown
  • EWG's Food Scores 1
  • FDA UNII F7YI574GFD
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Nosiheptide Chemical Properties,Usage,Production

  • Uses Nosiheptide is a bicyclic thiopeptide antibiotic produced by several species of actinomycetes, notably Streptomyces, first reported by Japanese researchers in 1970. Unlike other bicyclic thiopeptides such as thiostrepton, the second macrocyclic ring is linked by relatively fragile lactone and thiolactone bridges to the core cyclic peptide. Nosiheptide has broad spectrum antibacterial activity, and has recently demonstrated a prolonged post-antibiotic effect in both nosocomial and community-acquired MRSA compared with vancomycin. Despite its long history in animal health, nosiheptide has not been extensively studied and is regarded as a “lost antibiotic” largely escaping intensive investigation for human application.
  • Uses Nosiheptide is an antibacterial item used in feedstock and feed additives for chickens.
  • Biological Activity mic: ≤ 0.25 mg/l for methicillin-resistant s. aureus strains; ≤ 0.125 mg/l for enterococcus spp; 0.008 mg/l for bi strain of c. difficilenosiheptide is a thiopeptide antibiotic.thiopeptides are a family of antibiotics counting with more than one hundred different entities. although thiopeptides are mainly isolated from soil bacteria, new members have been isolated from marine samples. thiopeptides have been reported to have a wide range of biological properties, such as antiplasmodial, anticancer, immunosuppressive, etc.
  • in vitro the mode of action of nosiheptide on bacterial protein synthesis was found to be closely similar to that of thiostrepton. both antibiotics could inhibit functions of elongation factors tu and g and could also significantly reduce the synthesis of guanosine penta- and tetraphosphates to stringent factor. in addition, the actinomycetes that produced nosiheptide were able to defend themselves against their products in similar fashion, which involved specific pentosemethylation of 23s ribosomal rna [1].
  • in vivo the rhdl–nosiheptide complex was intravenously administered to male wistar rats and the distribution of nosiheptide in the liver and plasma was monitored 30 min after injection. results showed that the hepatic distribution of the rhdl–nosiheptide complex accounted for most of the administered nosiheptide, and was seven times as much as that in plasma. these findings indicated that the rhdl–nosiheptide complex could targete nosiheptide to the liver [2].
  • References [1] e. cundliffe and j. thompson. the mode of action of nosiheptide (multhiomycin) and the mechanism of resistance in the producing organism. j.gen.microbiol. 126(1), 185-192 (1981).
    [2] feng m, cai q, shi x, huang h, zhou p, guo x. recombinant high-density lipoprotein complex as a targeting system of nosiheptide to liver cells. j drug target. 2008 jul;16(6):502-8.
Nosiheptide Preparation Products And Raw materials
Raw materials
Preparation Products
Nosiheptide Suppliers
Global(130)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
  • ProdList：29730
  • Advantage：60
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    SIMAGCHEM CORP
  • Tel： +86-13806087780
  • Email：sale@simagchem.com
  • Country：China
  • ProdList：17365
  • Advantage：58
Nosiheptide Spectrum
56377-79-8, NosiheptideRelated Search:
  • 抑制剂
  • 生化试剂
  • 饲料添加剂
  • 微生物代谢物
  • C51H43N13O12S6
  • 诺西肽(那西肽)
  • 那西肽,10 MM DMSO 溶液
  • 乙腈/二甲亚砜中那西肽
  • 甲醇/二甲基亚砜中那西肽
  • N-(3-氨基-3-氧代丙-1-烯-2-基)-2-((11S,14Z,21S,23S,29S)-14-亚乙基-3,23-二羟基-11-((1R)-(1-羟乙基))-31-甲基-9,12,19,24,33,43-六氧代-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-十六氢-21,36-([2,4]-ENDO-THIAZOLOMETHANIMINO)-5,8:15,18:37,40-三(AZENO)-30,32-EPIMINO苯并[H1]吡啶并[3,2
  • 那西肽/诺肽菌素
  • N-(3-氨基-3-氧代丙-1-烯-2-基)-2-((11S,14Z,21S,23S,29S)-14-亚乙基-3,23-二羟基-11-((1R)-(1-羟乙基))-31-甲基-9,12,19,24,33,43-六氧代-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-十六氢-21,36-([2,4]-ENDO-THIAZOLOMETHANIMINO)-5,8:15,18:37,40-三(AZENO)-30,32-EPIMINO苯并[H1]吡啶并[3,2-V][1]氧杂[10,20,26,30]四硫杂[6,13,16]三氮杂环三十六烷-2-基)噻唑-4
  • 那西肽NOSIHEPTIDE
  • 诺肽菌素
  • 诺西肽
  • 那西肽
  • 那西肽90%
  • 那西肽1%预混粉
  • 56377-79-8
  • Nosiheptide, 10 mM in DMSO
  • Nosiheptide in DMSO
  • Nosiheptide premix(0.25%,0.5%,1%)
  • N-(3-Amino-3-oxoprop-1-en-2-yl)-2-((11S,14Z,21S,23S,29S)-14-ethylidene-3,23-dihydroxy-11-((1R)-(1-hydroxyethyl))-31-methyl-9,12,19,24,33,43-hexaoxo-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-21,36-([2,4]-endo-thiazolomethanimino)-5,8:15,18:37,40-tri(azeno)-30,32-epiminobenzo[h1]pyrido[3,2-v][1]oxa[10,20,26,30]tetrathia[6,13,16]triazacyclohexatriacontin-2-yl)thiazole-4-carboxamide
  • Nosiheptide USP/EP/BP
  • 4-Thiazolecarboxamide, N-[1-(aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanim...
  • RP 9671
  • CS-2680
  • 101159
  • Nosiheptide (Multhiomycin)
  • Multhiomycin
  • priMofax
  • Nosiheptide VETRANAL
  • N-[1-(Aminocarbonyl)ethenyl]-2-[(11S,14Z,21S,23S,29S)-14-ethylidene-9,10,11,12,13,14,19,20,21,22,23,24,26,33,35,36-hexadecahydro-3,23-dihydroxy-11-[(1R)-1-hydroxyethyl]-31-methyl-9,12,19,24,33,43-hexaoxo-30,32-imino-8,5:18,15:40,37-trinitrilo-21,36-([2,4]-endo-thiazolomethanimino)-5H,15H,37H-pyrido[3,2-w][2,11,21,27,31,7,14,17]benzoxatetrathiatriazacyclohexatriacontin-2-yl]-4-thiazolecarboxamide
  • Nosiheptide

Home

My