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ergotamine
- CAS No.113-15-5
- Chemical Name:ergotamine
- CBNumber:CB2865180
- Molecular Formula:C33H35N5O5
- Formula Weight:581.66
- MOL File:113-15-5.mol
ergotamine Property
- Melting point 241-249℃
- alpha D20 -160° (chloroform)
- Boiling point 651.33°C (rough estimate)
- Density 1.0998 (rough estimate)
- refractive index 1.7500 (estimate)
- pka pKa 6.40±0.09(H2O t=24.0) (Uncertain)
- optical activity -16020 (CHCl3)
- CAS DataBase Reference 113-15-5
- EWG's Food Scores 1
- FDA UNII PR834Q503T
- ATC code N02CA02
Safety
- RIDADR :1544
- HazardClass :6.1(b)
- PackingGroup :III
- Hazardous Substances Data :113-15-5(Hazardous Substances Data)
- Toxicity :LD50 in mice, rats, rabbits (mg/kg): 62, 80, 3 i.v.; in cats: 11 s.c. (Rothlin)
-
Symbol(GHS)
- Signal wordDanger
- Hazard statements H330-H311-H361-H301
- Precautionary statements P280-P302+P352-P312-P322-P361-P363-P405-P501-P201-P202-P281-P308+P313-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501
ergotamine Chemical Properties,Usage,Production
- Uses Analgesic (specific in migraine).
- Uses Ergotamine, 3′,6′,18′-trione,12′-hydroxy-2′-methyl-5′-benzyl-(5α)-ergotamine (12.2.14), is obtained via microbiological synthesis [52].As an α-adrenoblocker, ergotamine exhibits a direct vasoconstricting effect for which it is used in medicine, particularly for alleviation of severe migraine attacks. It is categorically counterproductive in chronic diseases because of the possibility of side effects such as triggering gangrene.
- Definition ChEBI: A peptide ergot alkaloid that is dihydroergotamine in which a double bond replaces the single bond between positions 9 and 10.
- brand name Ergomar (Harvest);Ergostat (Parke-Davis); Wigrettes (Organon).
- Purification Methods Crystallise it from *benzene, then dry it by prolonged heating in high vacuum. It is very hygroscopic. [Beilstein 25 III/IV 964.]
ergotamine Preparation Products And Raw materials
Raw materials
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113-15-5, ergotamineRelated Search:
- Ergotamine tartrate (7CI),Ergotamine, tartrate (2:1) (salt) (8CI),Medihaler-ergotamine,ERGOTAMINE D-TARTRATE, PH EUR,ERGOTAMINE TARTRATE DIHYDROERGOTAMINE DIHYDROERGOTAMINE MESYLATE ERGOCRISTINE ergotamine ERGTOXIN DIHYDROERGOTAMINE TARTRATE Bromocriptine DIHYDROERGOTAMINE MESYLATE Ergotaminine DIHYDROERGOTAMINE TARTRATE CRYSTALLINE ergostine Ergotamine tartrate·anhydrous caffeine ERGOTAMINE TARTRATE - * DRUG PRECURSOR L(-)-ERGOTAMINE-L(+)-TARTRATE Dosergoside ERGOTAMINE TARTRATE GüG WHO(CRM STANDARD) ERGOTAMINE,SHEEPANTI-
- Organics
- 甲磺酸二氢麦角胺杂质A
- 麦角胺/麦角胺碱/麦角碱
- 麦角胺
- 113-15-5
- (6aR,9R)-N-[(2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (ergotamine),
- ergotamin
- ergotamine USP/EP/BP
- Ergotaman-3',6',18-trione,12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'a)-
- XCGSFFUVFURLIX-VFGNJEKYSA-N
- (5'alpha)-12'-Hydroxy-2'-methyl-5'-(phenylmethyl)ergotaman-3',6',18-trione
- 12'-Hydroxy-2'-methyl-5'α-benzylergotaman-3',6',18-trione
- NSC 95090
- Ergotamine (8CI)
- Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α)-
- ergotamine
- 6’,18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-ergotaman-3(5’-alph
- 18-trione,12’-hydroxy-2’-methyl-5’-(phenylmethyl)-6(5’alpha)-ergotaman-3
- 12’-hydroxy-2’-methyl-5’alpha-(phenylmethyl)ergotaman-3’,6’,18-trione
