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Doramapimod

Doramapimod Structure
Doramapimod
  • CAS No.285983-48-4
  • Chemical Name:Doramapimod
  • CBNumber:CB2855127
  • Molecular Formula:C31H37N5O3
  • Formula Weight:527.66
  • MOL File:285983-48-4.mol
Doramapimod Property
  • Melting point 142-143 °C
  • Boiling point 631.6±55.0 °C(Predicted)
  • Density 1.20±0.1 g/cm3(Predicted)
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • solubility Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 30 mg/ml).
  • pka 13.47±0.70(Predicted)
  • form solid
  • color White or off-white
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
  • FDA UNII HO1A8B3YVV
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • HS Code  :2934999090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319-H335-H302+H312+H332-H315
  • Precautionary statements P301+P312-P302+P352-P305+P351+P338
Doramapimod Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: 506172
  • Product name : p38 MAP Kinase Inhibitor X, BIRB 796 - CAS 285983-48-4 - Calbiochem
  • Purity: The p38 MAP Kinase Inhibitor X, BIRB 796, also referenced under CAS 285983-48-4, controls the biological activity of p38 MAP Kinase. This small molecu
  • Packaging: 10MG
  • Price: ₹14260
  • Updated: 2022/06/14
  • Buy: Buy

Doramapimod Chemical Properties,Usage,Production

  • Description Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1?(IC50=18 nM). Displays anti-inflammatory activity2?but differential effects on inflammatory genes3. Cell permeable.
  • Chemical Properties Pale Beige Solid
  • Uses Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.
  • Definition ChEBI: A member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis.
  • in vitro birb 796 is a picomolar inhibitor of human p38 map kinase with a 12,000-fold increase in binding affinity. moreover, birb 796 behavors as one of the most potent and slowest dissociating human p38 map kinase inhibitors now known [1].
  • in vivo in a lps-stimulated tnf-α synthesis mouse model, a 65% inhibition of tnf-α synthesis was observed when birb 796 was dosed orally at 10 mg/kg. in a model of established collagen-induced arthritis using b10.riii mice, birb 796 showed a 63% inhibition of arthritis severity when dosed orally at 30 mg/kg qd [2].
  • storage Store at -20°C
  • References 1) Pargellis?et al. (2002),?Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site; Nat. Struct. Biol.,?9?268 2) Branger?et al.?(2002),?Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia; J. Immunol.,?168?4070 3) Joos?et al. (2010),?Differential effects of p38MAP kinase inhibitors on the expression of inflammation-associated genes in primary, interleukin-1 beta-stimulated human chondrocytes; Br. J. Pharmacol.,?160?1252
Doramapimod Preparation Products And Raw materials
Raw materials
Preparation Products
Doramapimod Suppliers
Global(182)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
  • Tel：+86-（0）57185586718<br/>+86-13336195806
  • Email：sales@capot.com
  • Country：China
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  • Advantage：60
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
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  • Supplier：
    Biochempartner
  • Tel：0086-13720134139
  • Email：candy@biochempartner.com
  • Country：CHINA
  • ProdList：965
  • Advantage：58
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
Doramapimod Spectrum
285983-48-4, DoramapimodRelated Search:
  • Inhibitors
  • MAPK
  • Protein Kinase Inhibitors and Activators
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Heterocycles
  • Aromatics
  • Anti-cancer&immunity
  • 信号转导通路激酶抑制剂
  • 抑制剂
  • 药靶配体
  • 合成有机化合物配体
  • 抗肿瘤药物
  • 医药中间体
  • 原料药
  • 定制化学品
  • 小分子抑制剂，天然产物
  • C31H37N5O3
  • 达马莫德,10 MM DMSO 溶液
  • DORAMAPIMOD,P38 MAPK抑制剂
  • 1-(1-对甲苯基-3-叔丁基-5-吡唑基)-3-[4-[2-(4-吗啉基)乙氧基]-1-萘基]脲
  • 1-(3-(叔丁基)-1-(对甲苯基)-1H-吡唑-5-基)-3-(4-(2-吗啉乙氧基)萘-1-基)脲
  • 度马莫德
  • 1-[2-(4-甲基苯基)-5-叔丁基吡唑-3-基]-3-[4-(2-吗啉-4-基乙氧基)萘-1-基]脲
  • 达马莫德
  • 多马莫德
  • 多马莫德,达马莫德
  • 脲, N-[3-(1,1-二甲基乙基)-1-(4-甲基苯基)-1H-吡唑-5-基]-N'-[4-[2-(4-吗啉基)乙氧基]-1-萘基]-
  • 多马莫德(抗癌类)
  • 285983-48-4
  • Doramapimod, 10 mM in DMSO
  • Doramapimod, p38 MAPK inhibitor
  • 1-[3-(tert-Butyl)-1-(p-tolyl)-5-pyrazolyl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea
  • p38 MAP Kinase Inhibitor X BIRB-796 Doramapimod
  • BIRB 796 (DoraMapiMod)
  • Doramapimod USP/EP/BP
  • BIRB-796;BIRB796
  • BIBR-796
  • CS-1863
  • BIRB 796 - BIRB 0796 | Doramapimod
  • CS-379
  • BIRB 796; BIRB-796; BIRB796;
  • 1-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1h-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
  • 3-[3-Tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
  • DORAMAPIMOD;BIRB 796;BIRB796
  • Doramapimod 1-(3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • 1-[2-(4-Methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea BIRB 796 (Doramapimod)
  • Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
  • doramapimod
  • BIRB 796
  • DoraMapiMod (BIRB-796)
  • DoraMapin BIBR796
  • N-[3-(1,1-DiMethylethyl)-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-Morpholinyl)ethoxy]-1-naphthalenyl]urea
  • BIRB 796BS
  • BIBR-796(DoraMapiMod)
  • DoraMapiMod, BIBR-796
  • 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea

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