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Hydroxyzine dihydrochloride

CAS No.2192-20-3
Chemical Name:Hydroxyzine dihydrochloride
CBNumber:CB2777401
Molecular Formula:C21H29Cl3N2O2
Formula Weight:447.83
MOL File:2192-20-3.mol

Hydroxyzine dihydrochloride Property

Melting point 190-192°C
Flash point 9℃
storage temp. 2-8°C
solubility H₂O: soluble
form powder
color White to Off-White
Water Solubility H2O: soluble
alcohol: soluble
chloroform: soluble
CAS DataBase Reference 2192-20-3(CAS DataBase Reference)
FDA UNII 76755771U3
EPA Substance Registry System Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride (2192-20-3)
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xn
Risk Statements :22-36/37/38
Safety Statements :26
WGK Germany :3
RTECS :KK2280000
HS Code :29335990
Toxicity :LD50 in rats (mg/kg): 126 i.p.; 950 orally (Goldenthal)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302-H336-H361d
Precautionary statements P202-P261-P264-P270-P301+P312-P308+P313

Hydroxyzine dihydrochloride Price More Price(2)

Brand: Sigma-Aldrich(India)
Product number: PHR1607
Product name : Hydroxyzine Dihydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹15934.4
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: H8885
Product name : Hydroxyzine dihydrochloride
Purity: ≥98%
Packaging: 10G
Price: ₹11496.15
Updated: 2022/06/14
Buy: Buy

Hydroxyzine dihydrochloride Chemical Properties,Usage,Production

Chemical Properties White Solid
Originator Atarax,UCB,France,1956
Uses Anti histamines
Uses Antihistaminic;H1 antogonist
Uses H1 receptor antagonist. Anxiolytic. Antihistaminic.
Uses Hydroxyzine dihydrochloride has been used in the study of comparative anxiolytic activity of various drugs in experimental models of rats.
Manufacturing Process A mixture of 0.1 mol of N-mono-1-p-chlorobenzohydrylpiperazine and 0.1 mol of 1-chloro-2-(2-hydroxy-ethoxy)-ethane is heated for 3 hours to 150°C. The mass is then taken up in 100 ml of benzene and 100 ml of a 10% aqueous solution of NaOH; decanting takes place, and the benzene solution is washed with water and the solvent is evaporated. Vacuum distilling of the residue yields 1-p-chlorobenzohydryl-4-[2-(2-hydroxy-ethoxy)-ethyl]-piperazine, BP 220°C/0.5 mm Hg.
The corresponding dihydrochloride is prepared by dissolving this base in about twice its weight of alcohol, by treating it with excess of gaseous HCl and by precipitating it with ether. The solvent is decanted and the residue, dissolved in a minimum of alcohol, crystallizes on the addition of ether, MP 193°C.
brand name Amplimexon (Amplimed).
Therapeutic Function Tranquilizer
General Description Hydroxyzine dihydrochloride is an antihistaminic drug and a member of the diphenylmethanes family. It exerts its action by blocking the action of histamine, a substance in the body that causes allergic symptoms.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions Hydroxyzine dihydrochloride (HDH) is used to regulate anxiety. It is also used to treat bronchial asthma and to relax patients before surgery.