Description
16,16-
dimethyl PGA
2 is a metabolism-
resistant analog of PGA
2 with a prolonged
in vivo half-
life. It inhibits the proliferation of Sendai virus in cultured African green monkey kidney cells by >90% at a concentration of 4 μg/ml. Daily infusion of 10 μg of 16,16-
dimethyl PGA
2 methyl ester into mice infected with influenza A virus increased survival by 40%. Similar treatment of mice inoculated with erythroleukemia cells delayed tumor growth and increased survival time.
Uses
16,16-dimethyl Prostaglandin A2 is a PGA2 analog studied for its antiproliferative properties.
Definition
ChEBI: 16,16-dimethyl-PGA2 is a prostanoid.
References
[1] M. G. SANTORO. Prostaglandin A Compounds as Antiviral Agents[J]. Science, 1980, 209 4460. DOI:
10.1126/science.6157190[2] M. G. SANTORO. Antiviral activity of a synthetic analog of prostaglandin A in mice infected with influenza A virus[J]. Archives of Virology, 1988, 99 1-2: 89-100. DOI:
10.1007/bf01311026[3] S MARINI. Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity[J]. British Journal of Cancer, 1990, 61 3: 394-399. DOI:
10.1038/bjc.1990.86
