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2-Iodopyridine

CAS No.5029-67-4
Chemical Name:2-Iodopyridine
CBNumber:CB2754297
Molecular Formula:C5H4IN
Formula Weight:205
MOL File:5029-67-4.mol

2-Iodopyridine Property

Melting point 118-120℃
Boiling point 52 °C (lit.)
Density 1.928 g/mL at 25 °C (lit.)
refractive index n20/D 1.6320(lit.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Solid
pka pK1:1.82(＋1) (25°C)
color Pale yellow
Water Solubility Slightly soluble in water.
Sensitive Light Sensitive
InChIKey CCZWSTFVHJPCEM-UHFFFAOYSA-N
CAS DataBase Reference 5029-67-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36
WGK Germany :3
Hazard Note :Irritant
HS Code :29333990

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

2-Iodopyridine Price More Price(6)

Brand: Sigma-Aldrich
Product number: 558761
Product name : 2-Iodopyridine
Purity: 98%
Packaging: 1G
Price: ₹6126.95
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 558761
Product name : 2-Iodopyridine
Purity: 98%
Packaging: 1G
Price: ₹6126.95
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: 558761
Product name : 2-Iodopyridine
Purity: 98%
Packaging: 5G
Price: ₹11929.15
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 558761
Product name : 2-Iodopyridine
Purity: 98%
Packaging: 5G
Price: ₹11929.15
Updated: 2022/06/14
Buy: Buy

Brand: TCI Chemicals (India)
Product number: I0533
Product name : 2-Iodopyridine (stabilized with Na2S2O3)
Purity: min. 98.0 %
Packaging: 5G
Price: ₹5900
Updated: 2022/05/26
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2-Iodopyridine Chemical Properties,Usage,Production

Chemical Properties Light yellow liquid
Uses 2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Uses 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors.
Reactions 2-Iodopyridine and 3-alkoxy-2-iodopyridines are oxidized by DMDO to give PyIO2 , which serve as oxidants for alcohols and sulfides.
In palladium-catalyzed aminocarbonylation of 2-iodopyridine, 3-iodopyridine and iodopyrazine were coupled with CO and various primary and secondary amines. The biologically relevant N-substituted nicotinamides and 3-pyridyl-glyoxylamides were obtained from 3-iodopyridine as a result of simple and double carbon monoxide insertions, respectively. The chemoselectivity towards the ketoamide can be increased by the elevation of CO pressure. On the other hand, N-alkyl and N-aryl-carboxamides were obtained exclusively from CO pressure of 1 to 90 bar by using 2-iodopyridine and iodopyrazine.

Pd-catalyzed aminocarbonylation of 2-iodopyridine and 3-iodopyridine with primary and secondary amines.
Synthesis Reference(s) Tetrahedron Letters, 31, p. 6757, 1990 DOI: 10.1016/S0040-4039(00)97163-6
General Description 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.