Description
Helvolic acid is a mycotoxin originally isolated from
A. fumigatus that has broad-spectrum antibiotic activity against Gram-positive and Gram-negative bacteria. At 4-16 mg/L, it acted synergistically with erythromycin (500-2,000 mg/L)
in vitro on five multi-drug resistant strains of
S. aureus. At 10 mg/kg/d, it reduced tumor growth and prolonged survival synergistically with cyclophosphamide (20 mg/kg/d) in a mouse model of sarcoma but had no effect when administered alone.
Definition
ChEBI: A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] PAMODA B RATNAWEERA. Helvolic acid, an antibacterial nortriterpenoid from a fungal endophyte, Xylaria sp. of orchid Anoectochilus setaceus endemic to Sri Lanka.[J]. Mycology, 2014, 5 1: 23-28. DOI:
10.1080/21501203.2014.892905[3] LING QIN. In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus.[J]. Natural Product Research, 2009, 23 4: 309-318. DOI:
10.1080/14786410801972813[4] JIAN-HUI XIAO. Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model.[J]. Experimental Biology and Medicine, 2017, 242 2: 214-222. DOI:
10.1177/1535370216668051
