Uses
ChemicalBook > CAS DataBase List > 3,6-DIOXAOCTANEDIOIC ACID

3,6-DIOXAOCTANEDIOIC ACID

Uses
3,6-DIOXAOCTANEDIOIC ACID Structure
3,6-DIOXAOCTANEDIOIC ACID
  • CAS No.23243-68-7
  • Chemical Name:3,6-DIOXAOCTANEDIOIC ACID
  • CBNumber:CB2499237
  • Molecular Formula:C6H10O6
  • Formula Weight:178.14
  • MOL File:23243-68-7.mol
3,6-DIOXAOCTANEDIOIC ACID Property
  • Melting point 68-71℃
  • Boiling point 429.2±25.0 °C(Predicted)
  • Density 1.375
  • vapor pressure 0Pa at 20℃
  • storage temp. Keep in dark place,Sealed in dry,Room Temperature
  • pka 3.09±0.10(Predicted)
  • form solid
  • color White to off-white
  • LogP -2.29 at 25℃
  • FDA UNII 2ZVS8WS40O
  • UNSPSC Code 12352301
Safety
  • Hazard Codes  :C
  • Risk Statements  :34
  • Safety Statements  :26-36/37/39-45-27-22
  • RIDADR  :3261
  • HazardClass  :8
  • PackingGroup  :III
  • HS Code  :2917198090
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H332-H315-H319-H335
  • Precautionary statements P260-P280-P312

3,6-DIOXAOCTANEDIOIC ACID Chemical Properties,Usage,Production

  • Uses 3,6-Dioxaoctanedioic Acid (cas# 23243-68-7) is a useful research chemical.
  • Description PEG2-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
  • Uses 3,6-Dioxaoctanedioic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
  • Uses 3,6-Dioxaoctanedioic Acid is a useful reagent for the preparation of degradation agents for cyclin dependent kinase.
  • Flammability and Explosibility Not classified
  • Synthesis Synthesis_23243-68-7
    To 15 ml (0.33 mol) of nitric acid was added at 45??C while stirring 1 g of diethylene glycol from the overall amount of 5.9 g (0.06 mol), and the mixture was heated to 65??C. After the end of nitrogen oxides evolution and cooling the mixture to 45-50??C another portion of diethylene glycol was added. Overall time of the reagent addition to the reaction mixture was 1 h. The mixture was kept at 45??C for 40 min and then it was heated at 80??C for 30 min. The solvent was removed in a vacuum at 70??C, the residue was dried by azeotropic distillation with benzene using Dean-Stark trap, then the product was fi ltered off and recrystallized from acetone-benzene mixture. 3,6-Dioxaoctanedioic acid (VIII) was similarly obtained. Yield 7.3 g (89%), colorless crystals. Rf 0.20 (E), mp 76-77??C (mp 75-76??C [13]). IR spectrum, |í, cm-1: 3167 (OH), 2914 (CH), 1733 (C=O acid), 1410, 1229 (C-O), 1121 (C-O). Mass spectrum, m/z (Irel, %): 178.5 [M]+ (76), 200.9 (55), 216.8 (46).
  • IC 50 PEGs
3,6-DIOXAOCTANEDIOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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3,6-DIOXAOCTANEDIOIC ACID Spectrum
23243-68-7, 3,6-DIOXAOCTANEDIOIC ACIDRelated Search:
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  • 23243-68-7
  • 3,6-DIOXAOCTANEDIOIC ACID
  • HOOCCH2O-PEG1-CH2COOH/Acetic acid, 2,2'-[1,2-ethanediylbis(oxy)]bis-
  • 3, 6-dioxyoctaneic acid
  • DOODA
  • 2-[2-(carboxymethoxy)ethoxy]aceticaci
  • HOOCCH2O-PEG1-CH2COOH
  • 3,6-dioxa-1,8-octanedioic acid
  • 3,6-Dioxaoctanedioic acid CAS
  • 3,6-Dioxaoctane-1,8-dioic acid
  • 2,5-Dioxa-1,6-hexanedicarboxylic acid
  • 1,2-Bis(carboxymethoxy)ethane
  • 2,2'-[1,2-Ethanediylbis(oxy)]diacetic acid
  • 2,2'-(Ethylenebisoxy)diacetic acid
  • (Ethylenebisoxy)diacetic acid
  • 3,6-Dioxaoctandioic acid
  • 2,2′-(Ethylenbis(oxy))bisessigsure
  • 2,2'-[ethylenebis(oxy)]bisacetic acid
  • 2,2'-[ethylenebis(oxy)] bisacetic acid for synthesis
  • 2-[2-(Carboxymethyloxy)ethoxy]acetic acid
  • PEG2-(CH2CO2H)2
  • 3,6-dioxoctanedioic acid
  • 2,2'-(Ethane-1,2-diylbis(oxy))diacetic acid
  • (2-CARBOXYMETHOXYETHOXY)ACETIC ACID
  • Acetic acid, 2,2‘-[1,2-ethanediylbis(oxy)]bis-
  • Acetic acid, 2,2'-[1,2-ethanediylbis(oxy)]bis- (Triglycolic acid)
  • 3,6-Dioxasuberic acid

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