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STAUROSPORINE

CAS No.62996-74-1
Chemical Name:STAUROSPORINE
CBNumber:CB2486697
Molecular Formula:C28H26N4O3
Formula Weight:466.54
MOL File:62996-74-1.mol

STAUROSPORINE Property

Melting point 270°C
alpha D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
Boiling point 677.5±55.0 °C(Predicted)
Density 1.56±0.1 g/cm3(Predicted)
RTECS KD5084000
storage temp. 2-8°C
solubility DMSO: soluble
form White to pale yellow solid
pka 14.25±0.70(Predicted)
color Off white to pale yellow
Water Solubility Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
BRN 1060573
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey HKSZLNNOFSGOKW-WIFUGMKFSA-N
CAS DataBase Reference 62996-74-1
NCI Dictionary of Cancer Terms staurosporine
FDA UNII H88EPA0A3N
UNSPSC Code 12352200
NACRES NA.77

Safety

Hazard Codes :Xn,T,Xi
Risk Statements :40-45-36/37/38-46
Safety Statements :36/37-53-36-26-45
RIDADR :UN 2811 6.1 / PGII
WGK Germany :2
F :8-10
HazardClass :3
HS Code :29419090

NFPA 704:

	0
4		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H361d-H413
Precautionary statements P201-P202-P273-P280-P308+P313-P405

STAUROSPORINE Price More Price(14)

Brand: Sigma-Aldrich(India)
Product number: S5921
Product name : Staurosporine from Streptomyces sp.
Purity: for molecular biology, ≥95% (HPLC)
Packaging: 0.1MG
Price: ₹24540.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: S5921
Product name : Staurosporine from Streptomyces sp.
Purity: for molecular biology, ≥95% (HPLC)
Packaging: 0.5MG
Price: ₹82118.45
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich
Product number: S5921
Product name : Staurosporine from Streptomyces sp.
Purity: for molecular biology, ≥95% (HPLC)
Packaging: 1MG
Price: ₹146256.58
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: S5921
Product name : Staurosporine from Streptomyces sp.
Purity: for molecular biology, ≥95% (HPLC)
Packaging: 1MG
Price: ₹146256.58
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: S4400
Product name : Staurosporine from Streptomyces sp.
Purity: ≥98% (HPLC), film
Packaging: 0.1MG
Price: ₹23262.93
Updated: 2022/06/14
Buy: Buy

STAUROSPORINE Chemical Properties,Usage,Production

Description Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC₅₀ value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.
Chemical Properties Light Yellow Solid
Occurrence A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.
Uses Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
Uses Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
Definition ChEBI: Staurosporine is an indolocarbazole alkaloid and an organic heterooctacyclic compound. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a geroprotector, a bacterial metabolite and an apoptosis inducer. It is a conjugate base of a staurosporinium.
General Description A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC₅₀ = 20 nM), myosin light chain kinase (IC₅₀ = 1.3 nM), protein kinase A (IC₅₀ = 7 nM), protein kinase C (IC₅₀ = 0.7 nM), and protein kinase G (IC₅₀ = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G₁ checkpoint.
Biological Activity Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions Reversible: yes
storage +4°C
References 1) Omura et al. (1977) A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization; J. Antibiot., 30 275 2) Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases; Trends in Pharmacological Science 10 218