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t-Boc-N-Amido-PEG8-propargyl

t-Boc-N-Amido-PEG8-propargyl Structure
t-Boc-N-Amido-PEG8-propargyl
  • CAS No.2183440-31-3
  • Chemical Name:t-Boc-N-Amido-PEG8-propargyl
  • CBNumber:CB24849672
  • Molecular Formula:C24H45NO10
  • Formula Weight:507.61
  • MOL File:2183440-31-3.mol
t-Boc-N-Amido-PEG8-propargyl Property
  • Boiling point 565.0±50.0 °C(Predicted)
  • Density 1.076±0.06 g/cm3(Predicted)
  • solubility Soluble in DMSO, DCM, DMF
  • pka 12.23±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

t-Boc-N-Amido-PEG8-propargyl Chemical Properties,Usage,Production

  • Description t-Boc-N-Amido-PEG8-propargyl has an alkyne group and Boc-protected amine. The alkyne group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry. The deprotection of Boc-protected amine can be peformed under mild acidic conditions. The hydrophilic PEG chain enhances the solubility of the molecule in aqueous solution.
  • Uses Boc-NH-PEG8-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-NH-PEG8-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-N-Amido-PEG8-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-N-Amido-PEG8-propargyl Suppliers
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t-Boc-N-Amido-PEG8-propargyl Spectrum
2183440-31-3, t-Boc-N-Amido-PEG8-propargylRelated Search:
  • peg
  • PEG系列产品-Propargy-PEG系列
  • 助剂
  • 213440-31-3
  • T-BOC-N-酰胺-八聚乙二醇-丙炔
  • 叔丁氧羰基氨基-八聚乙二醇-炔基
  • 丙炔-八聚乙二醇-氨基叔丁酯
  • 叔丁氧羰基-PEG8-丙炔
  • 2183440-31-3
  • 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester
  • Propargyl-PEG8-NHBoc/5,8,11,14,17,20,23,26-Octaoxa-2-azanonacos-28-ynoic acid, 1,1-dimethylethyl ester
  • Boc-NH-PEG8-Alkyne
  • Propargyl-PEG9-Boc Amine
  • Propargyl-PEG8-NHBoc
  • Boc-NH-PEG8-propargyl
  • t-Boc-N-Amido-PEG8-propargyl

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