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HOECHST 33258

HOECHST 33258 Property

Melting point 314 °C
Boiling point 746.9±70.0 °C(Predicted)
Density 1.355±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility H₂O: 10 mg/mL
pka 9.23±0.15(Predicted)
form powder
color Light yellow to yellow
Stability Stable. Incompatible with strong oxidizing agents. Light sensitive.
FDA UNII LHQ7J5KV9B
NCI Drug Dictionary pibenzimol
EPA Substance Registry System Phenol, 4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]- (23491-44-3)

Safety

Hazard and Precautionary Statements (GHS)

HOECHST 33258 Chemical Properties,Usage,Production

Chemical Properties yellow solid
Uses Hoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].
Definition ChEBI: Pibenzimol is a bibenzimidazole and a N-methylpiperazine. It has a role as a fluorochrome and an anthelminthic drug.
References [1] Wang XJ, et al. Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through inductionof apoptosis and autophagy. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6297-300. DOI:10.1016/j.bmcl.2012.06.102
[2] Stoli? I, et al. Synthesis, DNA/RNA affinity and antitumour activity of new aromatic diamidines linked by 3,4-ethylenedioxythiophene. Eur J Med Chem. 2011 Feb;46(2):743-55. DOI:10.1016/j.ejmech.2010.12.010

HOECHST 33258 Preparation Products And Raw materials

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HOECHST 33258 Spectrum

23491-44-3, HOECHST 33258Related Search:

抑制剂
Reagents
Apoptosis Detection
Apoptosis and Cell Cycle
BioChemical
Cell Signaling and Neuroscience
Cell Biology
C25H24N6O
4-(5-[5-(4-甲基-1-哌嗪基)-2H-苯并咪唑-2-亚基]-5H-苯并咪唑-2-基)苯酚
4-(5-(4-甲基哌嗪-1-基)-1H,1'H-[2,5'-联苯并[D]咪唑]-2'-基)苯酚
赫斯特荧光染料 33258(游离)
23491-44-3
4-(5-(4-Methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)phenol
Phenol, 4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-
P-(5-(5-(4-METHYL-1-PIPERAZINYL)-2-BENZIMIDAZOLYL)-2-BENZIMIDAZOLYL)PHENOL
pibenzimol
p-(5-(5-(4-methyl-1-piperazinyl)-2-benzimidazolyl)-2-benzimidazolyl)-pheno
bisbenzimidazole
4-[5-(4-methyl-1-piperazinyl)[2,5’-bi-1h-benzimidazol]-2’-yl]-pheno
Bisbenzimidazol
4-[6-[6-(4-Methylpiperazino)-1H-benzimidazole-2-yl]-1H-benzimidazole-2-yl]phenol
4-[6'-(4-Methylpiperazino)-6,2'-bi[1H-benzimidazole]-2-yl]phenol
4-(5-(4-methyl-1-piperazinyl)(2,5’-bi-1h-benzimidazol)-2’-yl)-pheno
Bisbenzimide,2-(4-hydroxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5-bi-1H-benzimidazole,trihydrochloride
bis-benzimide (hydroxyphenyl form)
4-(5-(4-METHYL-1-PIPERAZINYL)(2,5''-BI-1H-BENZIMIDAZOL)2''-YL)PHENOL
p-(5-(5-(4-methylpiperazin-1-yl)benzimidazol-2-yl)benzimidazol-2-yl)phenol
hoechst 33258 (bisbenzimide)
bisbenzimide trihydrochloride cell*culture tested
CELLSTAIN- HOECHST 33258 SOLUTION
BISBENZIMIDE TRIHYDROCHLORIDE HYDRATE
BISBENZIMIDE H 33258
2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-1H-BENZIMIDAZOLE TRIHYDROCHLORIDE HYDRATE