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Menatetrenone

CAS No.863-61-6
Chemical Name:Menatetrenone
CBNumber:CB2471321
Molecular Formula:C31H40O2
Formula Weight:444.65
MOL File:863-61-6.mol

Menatetrenone Property

Melting point 350C
Boiling point 494.59°C (rough estimate)
Density 1.0461 (rough estimate)
refractive index 1.5045 (estimate)
Flash point 2℃
storage temp. -20°C
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form Solid
color Light Yellow to Yellow Oil
InChIKey DKHGMERMDICWDU-GHDNBGIDSA-N
CAS DataBase Reference 863-61-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 27Y876D139
NCI Drug Dictionary menatetrenone
UNSPSC Code 41116107
NACRES NA.79

Safety

Safety Statements :22-24/25
RIDADR :UN 1648 3 / PGII
WGK Germany :3
RTECS :QL9279500
HS Code :2914699000
Toxicity :LD50 intravenous in dog: > 40mL/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H302+H312+H332-H319
Precautionary statements P210-P280-P305+P351+P338

Menatetrenone Price More Price(4)

Brand: Sigma-Aldrich(India)
Product number: V9378
Product name : Vitamin K2
Purity:
Packaging: 250MG
Price: ₹10684.28
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: V9378
Product name : Vitamin K2
Purity:
Packaging: 1G
Price: ₹29703.8
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: V-031
Product name : Vitamin K2 (MK-4) solution
Purity: 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1ML
Price: ₹10543.55
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: 47774
Product name : Menaquinone (K2)
Purity: analytical standard
Packaging: 100MG
Price: ₹5758.9
Updated: 2022/06/14
Buy: Buy

Menatetrenone Chemical Properties,Usage,Production

Description Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.
Chemical Properties A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light.
Occurrence Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil.
Uses Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.
Definition ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent.
Preparation It can be extracted from millet leaves and rotten fish, and can also be synthesized with 2-menaquinone-1,4.
General Description Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.
Biochem/physiol Actions Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.
References https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone