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OM99-2

OM99-2 Structure
OM99-2
  • CAS No.314266-76-7
  • Chemical Name:OM99-2
  • CBNumber:CB2421700
  • Molecular Formula:C41H64N8O14
  • Formula Weight:892.99
  • MOL File:314266-76-7.mol
OM99-2 Property
  • Boiling point 1346.5±65.0 °C(Predicted)
  • Density 1.289±0.06 g/cm3(Predicted)
  • storage temp. −20°C
  • pka 3.48±0.10(Predicted)
  • form solid
  • FDA UNII 4ZNA144ZS0
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
OM99-2 Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: G8291
  • Product name : Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe
  • Purity: >93% (HPLC), solid
  • Packaging: 0.5MG
  • Price: ₹95530.63
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 496000
  • Product name : InSolution OM99-2 - CAS 314266-76-7 - Calbiochem
  • Purity: An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.
  • Packaging: 250μG
  • Price: ₹62190.01
  • Updated: 2022/06/14
  • Buy: Buy

OM99-2 Chemical Properties,Usage,Production

  • Uses OM99-2, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM[1]. OM99-2 is significantly advanced the development of BACE1 inhibitor[2]. OM99-2 has the potential for the research of the Alzheimer's disease[3].
  • Biological Activity Cell permeable: no', 'Primary Target
    human brain memapsin 2', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 1.6 nM against recombinant memapsin 2; 9.58 nM against recombinant pro-memapsin 2; 48 nM against cathepsin D
  • IC 50 BACE1
  • References [1] Ghosh AK, et al. Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase). J Am Chem Soc. 2000;122(14):3522-3523. DOI:10.1021/ja000300g
    [2] Zhao J, et al. Targeting Amyloidogenic Processing of APP in Alzheimer's Disease. Front Mol Neurosci. 2020;13:137. Published 2020 Aug 4. DOI:10.3389/fnmol.2020.00137
    [3] Dash C, et al. Aspartic peptidase inhibitors: implications in drug development. Crit Rev Biochem Mol Biol. 2003;38(2):89-119. DOI:10.1080/713609213
    [4] Park H, et al. Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design. J Am Chem Soc. 2003;125(52):16416-16422. DOI:10.1021/ja0304493
OM99-2 Preparation Products And Raw materials
Raw materials
Preparation Products
OM99-2 Suppliers
Global(38)Suppliers
  • Supplier：
    Nanjing TGpeptide
  • Tel：+86-13347807150<br/>+86-13347807150
  • Email：support@tgpeptide.com
  • Country：China
  • ProdList：3279
  • Advantage：58
  • Supplier： GL Biochem (Shanghai) Ltd
  • Tel：21-61263452<br/>13641803416
  • Email：ymbetter@glbiochem.com
  • Country：China
  • ProdList：9981
  • Advantage：64
  • Supplier： BOC Sciences
  • Tel：1-631-485-4226;<br/>16314854226
  • Email：info@bocsci.com
  • Country：United States
  • ProdList：12952
  • Advantage：65
  • Supplier： Creative Peptides
  • Tel：
  • Email：info@creative-peptides.com
  • Country：United States
  • ProdList：6083
  • Advantage：56
  • Supplier： Nanjing Peptide Biotech Ltd.
  • Tel：025-025-58361106-805-805<br/>13082558573
  • Email：liugang@njpeptide.com
  • Country：China
  • ProdList：9980
  • Advantage：55
OM99-2 Spectrum
314266-76-7, OM99-2Related Search:
  • Substrates by Enzyme
  • Protease Substrates
  • Neuropeptides
  • Galanins
  • Enzyme Substrates
  • Galanin degrading zinc-metallopeptidasePeptides for Cell Biology
  • Galanin Degrading Zinc-MetallopeptidaseEnzyme Substrates
  • 多肽
  • beta-Secretase
  • BioChemical
  • Biochemicals and Reagents
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • R to Z
  • C41H64N8O14
  • C72H98N18O20
  • 314266-76-7
  • Glu-Val-Asn-[(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-Ala-Glu-Phe >93% (HPLC), solid
  • L-Phenylalanine, L-α-glutamyl-L-valyl-L-asparaginyl-(2R,4S,5S)-5-amino-4-hydroxy-2,7-dimethyloctanoyl-L-alanyl-L-α-glutamyl-
  • InSolution OM99-2 - CAS 314266-76-7 - Calbiochem
  • InSolution? OM99-2
  • OM99-2;[2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE, HUMAN TRIFLUOROACETATE SALT
  • glu-val-asn-[(2r,4s,5s)-5-amino-4-hydroxy-2,7-dimethyloctanoyl]-ala-glu-phe
  • [2-aminobenzoyl-gly1]-galanin fragment (1-10)-lys(retro-m-nitro-tyr) amide, human trifluoroacetate salt
  • [2-AMINOBENZOYL-GLY1]-GALANIN FRAGMENT (1-10)-LYS(RETRO-M-NITRO-TYR) AMIDE HUMAN
  • GLU-VAL-ASN-(2R,4S,5S)-5-AMINO-*4-HYDROXY-2,7-DIMET
  • EVNL-PSI-AAEF
  • H-GLU-VAL-ASN-[(2R,4S,5S)-5-AMINO-4-HYDROXY-2,7-DIMETHYL-OCTANOYL]-ALA-GLU-PHE-OH
  • OM99-2

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